{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:50:54Z","timestamp":1783619454305,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac resynchronization therapy demonstrated benefits in heart failure. However, only 60\u201370% are responders and only 22% are super\u2010responders. MultiPoint pacing (MPP) improves structural remodeling, but data in responder patients is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, randomized study of the efficacy of MPP was conducted in patients who were CRT responders after 6 months of bi\u2010ventricular (BiV) therapy. At 6 months, responder patients (LV end\u2010systolic volume [LVESV] reduction \u226515%) were randomized to either continued BiV therapy or to MPP programmed with wide anatomical separation \u226530\u00a0mm, and followed until 12 months. Efficacy was determined by 6\u201312 month changes in LVESV and LV ejection fraction (LVEF). Evaluations of super\u2010responder rate (LVESV reduction \u226530%) and quality of life (NYHA, EQ\u20105D, MLHFQ) were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From February 2017 to February 2019, 73 CRTs with Quartet LV leads were implanted (42.9% female, 65.7 \u00b1 10.8 years old, 79.5% dilated cardiomyopathy). At 6 months, 74.2% responded to BiV and were randomized to BiV (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) or MPP (<jats:italic>n<\/jats:italic>\u00a0=\u00a024). MPP versus BiV delivered greater LVESV improvement (8.3% decrease in MPP vs. 10.3% increase in BiV patients, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.047), greater increase in LVEF (7.7%\u00a0vs. 1.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008), and higher 0\u201312 month super\u2010responder rate (86.4%\u00a0vs. 56.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027). More MPP vs. BiV patients experienced an improvement in NYHA (84.6%\u00a0vs. 50.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.047) and EQ\u20105D (94.4%\u00a0vs. 54.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MPP with wide anatomical spacing in CRT responder patients resulted in improved LV reverse remodeling with higher rates of super\u2010responders, and better quality of life metrics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14319","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T17:16:39Z","timestamp":1626196599000},"page":"1577-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical impact of MultiPoint pacing in responders to cardiac resynchronization therapy"],"prefix":"10.1111","volume":"44","author":[{"given":"Pedro","family":"Marques","sequence":"first","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio Lisboa Norte  Lisboa Portugal"},{"name":"CAML, CCUL, Lisbon School of Medicine Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-9497","authenticated-orcid":false,"given":"Afonso","family":"Nunes\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio Lisboa Norte  Lisboa Portugal"},{"name":"CAML, CCUL, Lisbon School of Medicine Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Silv\u00e9rio Ant\u00f3nio","sequence":"additional","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio Lisboa Norte  Lisboa Portugal"},{"name":"CAML, CCUL, Lisbon School of Medicine Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9951-1104","authenticated-orcid":false,"given":"In\u00eas","family":"Aguiar\u2010Ricardo","sequence":"additional","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio Lisboa Norte  Lisboa Portugal"},{"name":"CAML, CCUL, Lisbon School of Medicine Universidade de Lisboa  Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-1251","authenticated-orcid":false,"given":"Tiago","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Cardiology Department Centro Hospitalar Universit\u00e1rio Lisboa Norte  Lisboa Portugal"},{"name":"CAML, CCUL, Lisbon School of Medicine Universidade de Lisboa  Lisboa 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