{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:49:56Z","timestamp":1747187396944,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sleep apnea syndrome (SAS) has been reported to be associated with a higher incidence of ventricular arrhythmias. The aim of this study was twofold: (1) to investigate whether in SAS patients receiving an implantable cardioverter defibrillator (ICD) the severity of SAS was associated with the occurrence of ventricular arrhythmias; (2) to assess whether changes in nocturnal apnoic\/hypopnoic episodes may favor the occurrence of life\u2010threatening arrhythmias, that is, sustained ventricular tachycardia (VT)\/fibrillation (VF), requiring ICD intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 46 patients with documented SAS at polysomnography (apnea\/hypopnea index [AHI]\u00a0&gt;\u00a05) who also had a left ventricle ejection fraction (LVEF)\u00a0&lt;\u00a035% and, according to primary prevention indications, implanted an ICD (Boston Scientific Incepta) able to daily monitor apnoic\/hypopnoic episodes occurring during sleep. Patients were followed at 3\u2010month intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a mean follow\u2010up of 18 months, 21 episodes of sustained VT\/FV requiring ICD intervention were documented in eight patients (17.4%). Baseline AHI was significantly higher in patients with compared to those without ICD intervention. ICD interventions, however, were not preceded by any worsening of apnoic\/hypopnoic episodes. The respiratory disturbance index (RDI) of the week during the event, indeed, was not different from that recorded during the previous 2\u00a0weeks (25.4 \u00b1 11, 25.6 \u00b1 10 and 25.1 \u00b1 10, respectively; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with SAS who received an ICD for primary prevention of sudden death, those with ICD interventions showed a more severe form of the disease at baseline. ICD interventions, however, were not preceded by any significant changes in SAS severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14328","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T15:05:46Z","timestamp":1627398346000},"page":"1657-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severity of spleep apnea syndrome and life\u2010threatening tachyarrhythmias in patients with implantable cardioverter defibrillator"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4737-1143","authenticated-orcid":false,"given":"Gianluigi","family":"Bencardino","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Vitulano","sequence":"additional","affiliation":[{"name":"Division of Cardiology Miulli General Hospital  Acquaviva delle Fonti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3938-4948","authenticated-orcid":false,"given":"Antonio","family":"Bisignani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca Augusta","family":"Gabrielli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3236-3458","authenticated-orcid":false,"given":"Gemma","family":"Pelargonio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lucia","family":"Narducci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Pinnacchio","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Comerci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano Antonio","family":"Lanza","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Sciences Fondazione Policlinico Universitario A. 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