{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:30:38Z","timestamp":1763224238939,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>His bundle pacing (HBP) is a physiological pacing strategy to preserve the electrical synchrony of ventricular conduction and left ventricular (LV) function. Left bundle branch pacing (LBBP) has emerged as an alternative physiological pacing technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate cardiac electrical and mechanical synchrony comparing LBBP and HBP in patients with permanent atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with symptomatic bradycardia and AF were enrolled from January to June of 2019. The cardiac electrical and mechanical synchrony in different pacing mode were evaluated at baseline and after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both HBP and LBBP were performed in 20 patients. LBBP significantly widened the QRS duration compared with the intrinsic conduction (113.2 \u00b1 14.5\u00a0 vs. 96.5 \u00b1 16.2\u00a0ms; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), while HBP did not (104.5 \u00b1 22.3\u00a0 vs. 96.5 \u00b1 16.2\u00a0ms; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.12). Both LBBP and HBP patients had similar LV myocardial strain measurements for the mechanical synchrony evaluation without significant change compared with baseline. There was no significant difference in right ventricular synchrony measurement between LBBP and HBP. Compared to HBP, LBBP had less interventricular synchrony (IMVD, 14.7 \u00b1 9.2\u00a0 vs. 3.1 \u00b1 12.7\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01; Ts\u2010LV\u2010RV, 37.9 \u00b1 10.7\u00a0 vs. 18.5 \u00b1 10.8\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although LBBP's a physiological pacing mode can achieve a similar cardiac electrical and mechanical synchronization when compared to HBP, LBBP results in modest delay in RV activation, and the clinical implication remains to be studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14331","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T04:55:00Z","timestamp":1627880100000},"page":"1523-1531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of synchronization between left bundle branch and his bundle pacing in atrial fibrillation patients: An intra\u2010patient\u2010controlled study"],"prefix":"10.1111","volume":"44","author":[{"given":"Xia","family":"Sheng","sequence":"first","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-7301","authenticated-orcid":false,"given":"Yi\u2010Wen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Ultrasound &amp; Echocardiography, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Ultrasound &amp; Echocardiography, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"},{"name":"Department of Cardiology Jinhua Wenrong Hospital  Jinhua 322118 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0327-1987","authenticated-orcid":false,"given":"Jie\u2010Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Quan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 310016 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