{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:28:35Z","timestamp":1785875315407,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although frequently considered a benign condition, new evidence has shown that mitral valve prolapse (MVP) is associated with complex ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Therefore, we conducted a systematic review and meta\u2010analysis of the relevant studies to investigate the parameters that could identify MVP patients at higher risk of experiencing complex VAs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We performed a systematic literature search of PubMed for potential studies between January 2010 and January 2021. Our meta\u2010analysis included studies comparing MVP patients with complex VAs (A\u2010MVP) and those without (NA\u2010MVP). We used the fixed\u2010effects model to obtain the odds ratio (OR), risk ratio (RR), or mean difference (MD) and 95% confidence interval (CI) for each analyzed parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies with 848 individuals were included in the meta\u2010analysis. As compared to the NA\u2010MVP patients, A\u2010MVP patients had a higher prevalence of inverted T\u2010wave (OR: 2.73; 95% CI: 1.85\u20104.02; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.00001) and longer QTc interval on the resting ECG (MD: 14.73; 95% CI: 9.39\u201020.08; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.00001), longer anterior mitral leaflet length (MD: 2.67; 95% CI: 2.02\u20103.31; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.00001), bi\u2010leaflet prolapse (OR: 1.65; 95% CI: 1.22\u20102.24; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), and mitral annulus disjunction (MAD) on echocardiogram (RR: 1.90; 95% CI: 1.50\u20102.40; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.00001), and late gadolinium enhancement (LGE) on cardiac magnetic resonance (RR: 4.38; 95% CI: 1.77\u201010.86; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our comprehensive meta\u2010analysis suggests that risk factors related to A\u2010MVP are T\u2010wave inversion, longer QTc interval, bi\u2010leaflet prolapse, longer anterior mitral valve leaflet, MAD, and LGE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14338","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T12:21:32Z","timestamp":1629116492000},"page":"1746-1755","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Arrhythmic mitral valve prolapse: Diagnostic parameters for high\u2010risk patients: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5946-0827","authenticated-orcid":false,"given":"Federico","family":"Oliveri","sequence":"first","affiliation":[{"name":"University of Pavia, Cardiology, California Institute of Behavioral Neurosciences &amp; Psychology Research  Pavia 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