{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T23:34:25Z","timestamp":1780875265740,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Drug\u2010induced atrioventricular block (AVB) is generally considered reversible and does not require a permanent pacemaker implantation (PPM). However, some studies have demonstrated a failure of AVB cessation even when the inducing agent has been discontinued. This study has investigated the use of systemic immune\u2010inflammation index (SII) to predict irreversible drug\u2010induced AVB after drug discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Files of patients with high\u2010degree AVB that required a temporary pacemaker (TPM) were retrospectively analyzed. Sixty\u2010three patients in which AVB was drug\u2010induced were included in the study. The patients were divided into the following two groups: (1) those whose AVB reversed after discontinuation of the related drug, and (2) those in which AVB did not reverse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AVB reversed in 24 patients (38%) after the inducing agent was discontinued while in the remaining 39 patients (62%) PPM was required. The most common drugs to induce AVB were beta\u2010blockers (n\u00a0=\u00a046, 73%). Follow\u2010up time with TPM was significantly longer in the irreversible group (2.91\u00a0\u00b1\u00a01.05\u00a0days vs. 4.94\u00a0\u00b1\u00a02.15\u00a0days, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Multivariate logistic regression analysis showed that SII (odds ratio [OR]\u00a0=\u00a01.002; 95% confidence interval [CI]\u00a0=\u00a01.000\u20131.003; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) was an independent predictor of the requirement for a PPM. An SII\u00a0&gt;\u00a0752.05 was found to be a predictor of irreversible AVB requiring PPM with a sensitivity of 64% and specificity of 75% (receiving\u2010operating characteristics [ROC] area under the ROC curve [AUC]: 0.704, 95% CI\u00a0=\u00a00.570\u20130.838, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately 2\/3 of drug\u2010induced high\u2010degree AVBs are irreversible. SII is an easily available and cheap inflammatory biomarker that can be used to predict irreversible AVB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14377","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T10:41:11Z","timestamp":1633776071000},"page":"1972-1978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systemic immune\u2010inflammation index as a tool for predicting the need for a permanent pacemaker in patients with drug\u2010induced atrioventricular block"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-7598","authenticated-orcid":false,"given":"Oktay","family":"\u015een\u00f6z","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bak\u0131rcay University Cigli Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Erse\u00e7gin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bak\u0131rcay University Cigli Training and Research Hospital  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2009.39.9.367"},{"key":"e_1_2_10_3_1","first-page":"29","article-title":"Severe iatrogenic bradycardia related to the combined use of beta\u2010blocking agents and sodium channel blockers","volume":"7","author":"Kawabata M","year":"2015","journal-title":"Clin Pharmacol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eul185"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000035996.46455.09"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12211"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.057"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2018.05.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.11.026"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2012.03410.x"},{"key":"e_1_2_10_11_1","first-page":"554","article-title":"Atrioventricular block in patients undergoing treatment with bradycardic drugs. Predictors of pacemaker requirement","volume":"73","author":"Martinez LJ","year":"2020","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.044"},{"key":"e_1_2_10_13_1","first-page":"e6953","article-title":"Delays in temporary and permanent pacemakers: causes and in\u2010hospital outcomes","volume":"12","author":"Irfan M","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","unstructured":"YangYL WuCH&HsuPFet al. Systemic immune\u2010inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. 2020;20(5):e13230.","DOI":"10.1111\/eci.13230"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/02676591211014822"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2021.1884786"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2012.03489.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.3.953"},{"key":"e_1_2_10_19_1","first-page":"344","article-title":"Complete atrioventricular block as initial manifestation of systemic lupus erythematosus","volume":"27","author":"Arce\u2010Salinas CA","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel315"},{"key":"e_1_2_10_21_1","first-page":"133","article-title":"Efficacy of corticosteroids in sarcoidosis presenting with atrioventricular block","volume":"20","author":"Kato Y","year":"2003","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1191\/096120301673172543"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.063"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1194612"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-006-6034-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.1010"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021511"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4933-2-14"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.14377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:47:46Z","timestamp":1693201666000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,24]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/pace.14377"],"URL":"https:\/\/doi.org\/10.1111\/pace.14377","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,24]]},"assertion":[{"value":"2021-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}