{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:00:25Z","timestamp":1761562825393,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005247","name":"University of British Columbia","doi-asserted-by":"publisher","award":["Cardiology academic practice plan"],"award-info":[{"award-number":["Cardiology academic practice plan"]}],"id":[{"id":"10.13039\/501100005247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Late potentials (LPs) identified on the signal averaged electrocardiogram (SAECG) are a marker for an increased risk of arrhythmias in Brugada syndrome (BrS). Procainamide is a sodium channel blocker used to diagnose BrS. The effects of Procainamide on the SAECG in those with BrS and the significance of Procainamide\u2010induced LPs are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Procainamide provocation was performed for suspected BrS with 12\u2010lead and SAECG pre\u2010 and post\u2010infusion. Filtered QRS duration (fQRSd), duration of low amplitude signals\u00a0&lt;40 \u03bcV (LAS40) and root\u2010mean\u2010square voltage in the terminal 40\u00a0ms (RMS40) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data from 150 patients were included in the analysis (mean age 44.5 years, 109 males). Procainamide increased fQRSd (Pre 118.8\u00a0\u00b1\u00a010.5\u00a0ms, post 121.2\u00a0\u00b1\u00a010.2\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and LAS40 (Pre 38.7\u00a0\u00b1\u00a09.8\u00a0ms, post 40.2\u00a0\u00b1\u00a010.5\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) and decreased RMS40 (Pre 24.6\u00a0\u00b1\u00a012\u00a0ms, post 22.8\u00a0\u00b1\u00a012\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). LPs were present in 68\/150 (45%) at baseline. Fifteen patients with negative baseline SAECGs had LPs unmasked by Procainamide, but six patients had LPs at baseline that were no longer present following Procainamide. Comparing those with normal hearts (<jats:italic>n<\/jats:italic>\u00a0=\u00a048) to those with a final diagnosis of BrS (<jats:italic>n<\/jats:italic>\u00a0=\u00a038), Procainamide prolonged fQRSd to a greater extent in those with BrS. Comparing those with Procainamide\u2010induced LPs to those with no LPs at any time did not highlight any aspect of phenotype and did not correlate with a history of ventricular arrhythmias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Procainamide influences the SAECG, provoking LPs in a small proportion of patients. However, there is no evidence that Procainamide\u2010induced LPs provide additional diagnostic information or aid risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14379","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T03:21:48Z","timestamp":1634440908000},"page":"2046-2053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The clinical utility of procainamide\u2010induced late potentials on the signal averaged ECG"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6743-9817","authenticated-orcid":false,"given":"Charles Michael","family":"Pearman","sequence":"first","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"},{"name":"Unit of Cardiac Physiology Division of Cardiovascular Sciences Manchester Academic Health Science Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdeep","family":"Walia","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Alqarawi","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"},{"name":"Department of Cardiac Sciences College of Medicine King Saud University  Riyadh Saudi Arabia"},{"name":"University of Ottawa Heart Institute  Ottawa Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Moesgaard","family":"Larsen","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"},{"name":"Department of Cardiology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Leach","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Krahn","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Laksman","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Innovation Heart Rhythm Services Division of Cardiology Department of Medicine University of British Columbia  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.06.037"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035954"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24128"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1102.105288"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.08.038"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.05.007"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2015.06.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1051"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853143"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060847"},{"key":"e_1_2_10_13_1","article-title":"Systematic re\u2010evaluation of SCN5A variants associated with Brugada syndrome","author":"Denham NC","year":"2018","journal-title":"J Cardiovasc Electrophysiol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.03.022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.01.026"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/oxfordjournals.eurheartj.a059926","article-title":"Standards for analysis of ventricular late potentials using high resolution or signal\u2010averaged electrocardiography. A statement by a Task Force Committee between the European Society of Cardiology, the American Heart Association and the American College of Cardiology","volume":"12","author":"Breithardt G","year":"1991","journal-title":"Eur Heart J"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1985.tb05784.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp252"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01888-0"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.972612"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.067"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1992.tb03032.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(88)90109-X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01197-4"},{"key":"e_1_2_10_26_1","first-page":"1900","article-title":"Non\u2010invasive assessment of the arrhythmogenic substrate in Brugada syndrome using signal\u2010averaged electrocardiogram: clinical implications from a prospective clinical trial","volume":"21","author":"Ciconte G","year":"2019","journal-title":"Europace"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2005.04313.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00685.x"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.14379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:48:14Z","timestamp":1693201694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,26]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/pace.14379"],"URL":"https:\/\/doi.org\/10.1111\/pace.14379","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2021,10,26]]},"assertion":[{"value":"2021-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}