{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:38:05Z","timestamp":1775828285816,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to assess whether left bundle branch area pacing (LBBAP) can result in favorable clinical and echocardiographic outcomes among patients with persistent atrial fibrillation (PeAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled consecutive patients with PeAF if they required ventricular pacing and had left ventricular ejection fraction (LVEF)\u00a0&gt;\u00a035%. During the same period, two experienced operators performed LBBAP and right ventricular pacing (RVP). All\u2010cause death and heart failure hospitalization (HFH) were routinely followed after procedure. The primary outcome was the composite endpoints of all\u2010cause death or HFH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LBBAP was successful in 49 of 52 patients (94.2%), whereas 44 patients received RVP. During a mean follow\u2010up of 13.9\u00a0\u00b1\u00a07.0 months, LBBAP group presented with higher ventricular pacing percentage (80% vs. 50.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) and narrower paced QRS duration (117.2\u00a0\u00b1\u00a018.8\u00a0ms vs. 151.8\u00a0\u00b1\u00a013.7\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) than RVP group. The primary endpoint was slightly reduced in LBBAP group than RVP without reaching statistical significance (7.7% vs. 11.4%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.48). Compared with baseline, we observed significant changes in LVEF (+0.7% vs. \u22122.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007) and left atrial diameter (\u22121.63\u00a0mm vs. +1.23\u00a0mm, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.011) between LBBAP and RVP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate possible effect of LBBAP on reverse remodeling of left atrium and a trend towards favorable clinical outcomes in patients with PeAF requiring high burden of ventricular pacing when compared with RVP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14394","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T16:40:34Z","timestamp":1635266434000},"page":"2024-2030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Left bundle branch area pacing versus right ventricular pacing in patients with persistent atrial fibrillation requiring ventricular pacing"],"prefix":"10.1111","volume":"44","author":[{"given":"Zhao","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojie","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-3839","authenticated-orcid":false,"given":"Xiaohan","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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