{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:51:22Z","timestamp":1758268282801,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulmonary vein (PV) isolation is an established treatment for paroxysmal drug\u2010refractory atrial fibrillation (AF). High parasympathetic tone and reconnection of PVs have demonstrated to be possible culprits of AF recurrence after ablation. Our aim was to investigate the association between parasympathetic tone and reconnected PVs in patients with paroxysmal AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent a redo catheter ablation procedure for atrial tachyarrhythmia recurrence by means of 3D electroanatomic mapping with documentation of presence or absence of PVs reconnection following an initial procedure of cryoballoon (CB) ablation for symptomatic drug\u2010refractory paroxysmal AF were screened for the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 92 patients were included, of whom 50 (54.35%) were males. Reconnected PVs were found in 64 (69%) patients. PVs reconnection could be predicted by DC (C\u2010statistic = .770), by SDNNI (C\u2010statistic = .714) and by absolute VLF power (C\u2010statistic = .722), while right\u2010sided PVs reconnection could be better predicted by DC (C\u2010statistic = .848) and by SDNNI (C\u2010statistic = .761). In multivariate binary logistic regression analysis, a DC value \u22656.45 ms and an absolute VLF power value \u2265160 ms<jats:sup>2<\/jats:sup> were associated with three times and five times higher odds of PVs reconnection, respectively. On a vein\u2010per\u2010vein analysis, absolute VLF power \u2265160 ms<jats:sup>2<\/jats:sup> was associated with three times higher odds, while reaching of \u221240\u00b0C within 60 s was associated with three times lower odds of PVs reconnection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High parasympathetic tonus accurately predicts PVs reconnection. On a vein\u2010per\u2010vein analysis, parasympathetic markers along with biophysical parameters predicted PVs reconnection. On a case\u2010by\u2010case analysis, parasympathetic markers were the only predictors of PVs reconnection, thus being a robust PVs reconnection prediction tool.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14408","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T10:10:42Z","timestamp":1636798242000},"page":"2075-2083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["High vagal tone predicts pulmonary vein reconnection after cryoballoon ablation for paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4948-2587","authenticated-orcid":false,"given":"Paul\u2010Adrian","family":"C\u0103lburean","sequence":"first","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"},{"name":"Department of Medical Informatics and Biostatistics, University of Medicine, Pharmacy Science and Technology \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u015f  T\u00e2rgu Mure\u015f Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Guimaraes","family":"Osorio","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Sorgente","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel \u2010 Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels 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