{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:39:37Z","timestamp":1782913177275,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate any association between non\u2010sustained ventricular tachycardia (NSVT) detected by intra\u2010cardiac device and clinical outcomes in repaired adult congenital heart disease (ACHD) without tetralogy of Fallot (TOF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>NSVT portends a higher risk of serious ventricular tachyarrhythmia in TOF. However its clinical significance when incidentally detected by implantable cardiac device is not well elucidated in non\u2010TOF ACHD cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single center, retrospective, longitudinal follow\u2010up study in repaired ACHD (\u226518 years) patients without TOF who hosted a pacemaker or automatic implantable cardiac defibrillator (AICD). The cohort was divided based on presence\/absence of device detected NSVT. The primary end\u2010point was a composite of sustained ventricular tachycardia (VT), ventricular fibrillation (VF), or sudden cardiac death (SCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty eight patients (male 56.3%, median [IQR] age of 35 [28\u201343] years at last follow\u2010up] with longitudinal post\u2010implant follow\u2010up duration of 8 (5\u201312) years were included. NSVT was detected in 52 (33%) patients. The primary composite end\u2010point was more frequent in NSVT group [11.5% vs. 2.8%; <jats:italic>p<\/jats:italic> = .04]. Patients with NSVT were (i) older at the time of initial implant (age 25 vs. 18 years, <jats:italic>p<\/jats:italic> = .011) and more frequently demonstrated (ii) systemic ventricular dysfunction (44% vs. 26%; <jats:italic>p<\/jats:italic> = .015), as well as (iii) history of ventriculotomy (38% vs. 21%; <jats:italic>p<\/jats:italic> = .017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our repaired ACHD cohort, we noted a significant association between device\u2010detected\u2010NSVT and the primary composite end\u2010point of sustained VT\/VF or SCD. Systemic ventricular dysfunction and history of ventriculotomy were more frequent in the NSVT group and likely constituted the clinical milieu.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14420","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T18:06:11Z","timestamp":1638381971000},"page":"302-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Device\u2010detected nonsustained ventricular tachycardia in adult congenital heart disease without tetralogy of fallot"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-294X","authenticated-orcid":false,"given":"Pezad","family":"Doctor","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Michigan Central Michigan University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan Central Michigan University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan Central Michigan University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan Central Michigan University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan Central Michigan University School of Medicine  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-4568","authenticated-orcid":false,"given":"Malini","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart Rhythm Services Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-209X","authenticated-orcid":false,"given":"Chenni S.","family":"Sriram","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Cardiology, Children's Hospital of Michigan Central Michigan University School of Medicine  Detroit Michigan 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