{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T19:06:08Z","timestamp":1769281568926,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The QT interval is of high clinical value as QT prolongation can lead to Torsades de Pointes (TdP) and sudden cardiac death. Insertable cardiac monitors (ICMs) have the capability of detecting both absolute and relative changes in QT interval. In order to determine feasibility for long\u2010term ICM based QT detection, we developed and validated an algorithm for continuous long\u2010term QT monitoring in patients with ICM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The QT detection algorithm, intended for use in ICMs, is designed to detect T\u2010waves and determine the beat\u2010to\u2010beat QT and QTc intervals. The algorithm was developed and validated using real\u2010world ICM data. The performance of the algorithm was evaluated by comparing the algorithm detected QT interval with the manually annotated QT interval using Pearson's correlation coefficient and Bland Altman plot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The QT detection algorithm was developed using 144 ICM ECG episodes from 46 patients and obtained a Pearson's coefficient of 0.89. The validation data set consisted of 136 ICM recorded ECG segments from 76 patients with unexplained syncope and 104 ICM recorded nightly ECG segments from 10 patients with diabetes and Long QT syndrome. The QT estimated by the algorithm was highly correlated with the truth data with a Pearson's coefficient of 0.93 (p &lt; .001), with the mean difference between annotated and algorithm computed QT intervals of \u22127 ms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term monitoring of QT intervals using ICM is feasible. Proof of concept development and validation of an ICM QT algorithm reveals a high degree of accuracy between algorithm and manually derived QT intervals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14431","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T12:54:42Z","timestamp":1640782482000},"page":"401-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The missing link: Unlocking the power of cardiac rhythm monitoring device based QT interval detection"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-207X","authenticated-orcid":false,"given":"Antony F.","family":"Chu","sequence":"first","affiliation":[{"name":"Warren Alpert School of Medicine Brown University, Rhode Island Hospital  593 Eddy St, APC Building, Division of Cardiology Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3083-5351","authenticated-orcid":false,"given":"Gautham","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"Medtronic Inc  8200 Coral Sea St. Mounds View Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantanu","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Medtronic Inc  8200 Coral Sea St. Mounds View Mounds View Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)02107-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.16.2120"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"17","article-title":"The QT interval: how long is too long?","volume":"9","author":"Cox Natalie 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