{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:48:18Z","timestamp":1768870098180,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background: Diagnosing arrhythmogenic right ventricular cardiomyopathy (ARVC) at an early stage can be challenging even after ECG recording and a combination of several imaging techniques. The purpose of this study was to explore if a body surface mapping (BSM) system with 252\u2010leads could identify repolarization abnormalities and thereby diagnose early stages of ARVC.<\/jats:p><jats:p>Methods: ARVC patients, gene carriers without signs of ARVC and controls underwent a 12\u2010lead resting ECG, signal\u2010averaged ECG, echocardiography, 24\u2010hours Holter monitoring, and BSM with electrocardiographic imaging (ECGI). All 252\u2010leads, divided into four quadrants of the vest, were analyzed regarding concordances between T wave polarity and QRS main vector.<\/jats:p><jats:p>Results: Of 40 patients included there were 12 ARVC patients, 20 gene carriers, and 8 controls. The ARVC patients had two different repolarization patterns, one with more pronounced negative T waves at the lower left panel and another with mixed changes that clearly differed from the controls, all of whom had a normal 12 lead ECGs and consistent repolarization patterns on their BSM recordings. The patterns observed in ARVC patients were also present in 5\/20 (25%) gene carriers, three of whom had normal resting ECG. A novel repolarization index successfully detected all ARVC patients and 88% of gene carriers with pathologic repolarization pattern.<\/jats:p><jats:p>Conclusions: The finding that abnormal repolarization patterns could be unmasked by BSM in 25% of healthy gene carriers, suggests that it may potentially be a useful tool for identifying early manifestations of ARVC. Further and larger studies are warranted to assess its diagnostic accuracy.<\/jats:p>","DOI":"10.1111\/pace.14456","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T18:25:58Z","timestamp":1643135158000},"page":"509-518","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Repolarization abnormalities unmasked with a 252\u2010lead BSM system in patients with ARVC and healthy gene carriers"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-5629","authenticated-orcid":false,"given":"Varvara","family":"Kommata","sequence":"first","affiliation":[{"name":"Department of Cardiology and Medical Science Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sciaraffia","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Medical Science Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2806-3903","authenticated-orcid":false,"given":"Carina","family":"Blomstr\u00f6m\u2010Lundqvist","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Medical Science Uppsala University  Uppsala 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and structural substrate of arrhythmogenic right ventricular cardiomyopathy determined using noninvasive electrocardiographic imaging and late gadolinium magnetic resonance imaging","author":"Andrews CM","year":"2017","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14295"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.12.2668"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4314"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus311"},{"key":"e_1_2_9_17_1","first-page":"175","article-title":"Screening relatives in arrhythmogenic right ventricular cardiomyopathy: yield of imaging and electrical investigations","volume":"21","author":"Jurlander R","year":"2020","journal-title":"Eur Heart J Cardiovasc 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