{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:16:58Z","timestamp":1793650618073,"version":"4.5.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, conduction system pacing, including His bundle and left bundle branch area pacing (LBBAP), has emerged as an alternative pacing procedure for right ventricular (RV) pacing. The current study aimed to compare the clinical outcomes of LBBAP and conventional RV midseptal pacing (RVMSP) in patients with heart failure (HF) with preserved ejection fraction (HFpEF) and HF with midrange ejection (HFmrEF) requiring frequency RV pacing due to atrioventricular block (AVB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 89 patients with HFpEF and HFmrEF requiring RV pacing due to symptomatic AVB were enrolled between September 2018 and April 2021, among whom 43 and 46 underwent LBBAP and RVMSP, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences in baseline characteristics were observed between the two groups. The LBBAP group had a significantly shorter paced\u2010QRS duration and paced left ventricular activation time (LVAT) compared to the RVMSP group (123.4 \u00b1 10.4\u00a0ms vs. 152.3 \u00b1 12.3\u00a0ms,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001 and 68.3 \u00b1 10.0\u00a0ms vs. 95.2 \u00b1 12.3\u00a0ms,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, respectively). The LBBAP group had significantly lower N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) levels at the 6\u2010month follow\u2010up compared to the RVMSP group [459.6 pg\/ml (240.4\u2013678.7) vs. 972.7 pg\/ml (629.5\u20131315.9),<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01]. More patients in the LBBAP group exhibited a significant improvement in NT\u2010proBNP, defined as a\u00a0&gt;\u00a050% decreased from baseline levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LBBAP maintains physiological ventricular activation and contributes to greater improvement in NT\u2010proBNP value 6 months after implantation in patients with HFpEF and HFmrEF compared to RVMSP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14470","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T10:58:39Z","timestamp":1645181919000},"page":"499-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical impact of left bundle branch area pacing in heart failure with preserved ejection fraction and mid\u2010range ejection fraction"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4034-5356","authenticated-orcid":false,"given":"Yousaku","family":"Okubo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukimi","family":"Uotani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehito","family":"Tokuyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hiroshima University Graduate School of Biomedical and Health Sciences Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.10.987"},{"key":"e_1_2_7_4_1","first-page":"3115","article-title":"Dual\u2010chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial","volume":"24","author":"Wilkoff 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