{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:50:16Z","timestamp":1747187416383,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with high risk of ventricular tachycardia (VT) the proven beneficial therapy is the implantable cardioverter defibrillator (ICD). It has been shown that the coronary artery disease (CAD) and VT development are accompanied by a persistent change of the sympathoadrenal system activity. This leads to a decrease in the total density of the erythrocyte membrane \u03b2\u2010adrenergic receptors. The purpose of this study was to identify the relationship of the erythrocyte membranes \u03b2\u2010adrenoreactivity (EMA) with VT development in patients with CAD and ICD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty\u2010three patients (male \u2010 53, age \u2010 66.6 \u00b1 9.2 years) with CAD and ICD were included to the study. EMA was studied using a method for assessing erythrocyte osmoresistance increase as a result of \u03b2\u2010adrenergic receptors blockade by a selective \u03b2\u2010adrenergic blocker. VT and ventricular fibrillation (VF) events recorded by ICD were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 1<jats:sup>st<\/jats:sup>group consist of 23 patients with VT\/VF events recorded by ICD during 27.0 [14.0; 53.0] months follow\u2010up period. EMA indicator in this group was 41.54% [27.15; 51.26]. The 2<jats:sup>nd<\/jats:sup>group consist of 40 patients without VT\/VF events and the same indicator was significantly higher \u2010 55.42% [35.67; 62.33] (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). The ROC\u2010analysis (AUC\u00a0=\u00a00.657; Sen\u00a0=\u00a078.26; Spe\u00a0=\u00a055.00;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.031) and binary logistic regression (OR\u00a0=\u00a00.9679; 95% CI: 0.9384\u20130.9983;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.038) showed that EMA indicator 51.26% or lower was the independent predictor of VT events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with CAD and ICD erythrocyte membranes \u03b2\u2010adrenoreactivity indicator 51.26% or lower is the predictor of VT episodes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14479","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T14:54:55Z","timestamp":1647269695000},"page":"452-460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ventricular tachycardia incidence and erythrocyte membranes \u03b2\u2010adrenoreactivity in patients with implanted cardioverter\u2010defibrillator"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-4142","authenticated-orcid":false,"given":"Tariel A.","family":"Atabekov","sequence":"first","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-3932","authenticated-orcid":false,"given":"Roman E.","family":"Batalov","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-9599","authenticated-orcid":false,"given":"Tatiana Yu.","family":"Rebrova","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-8287","authenticated-orcid":false,"given":"Sergey N.","family":"Krivolapov","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-2161","authenticated-orcid":false,"given":"Elvira F.","family":"Muslimova","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-5204","authenticated-orcid":false,"given":"Mikhail S.","family":"Khlynin","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6066-3998","authenticated-orcid":false,"given":"Sergey A.","family":"Afanasiev","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-4493","authenticated-orcid":false,"given":"Sergey V.","family":"Popov","sequence":"additional","affiliation":[{"name":"Cardiology Research Institute, Tomsk National Research Medical Centre Russian Academy of Sciences Tomsk Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.18087\/cardio.2018.12.10197"},{"issue":"13","key":"e_1_2_9_3_1","first-page":"272","article-title":"2017 AHA\/ACC\/HRS Guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines and the Heart Rhythm Society","volume":"138","author":"Al\u2010Khatib 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