{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:42:47Z","timestamp":1787755367511,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It has been observed that the fourth\u2010generation cryoballoon (CB4) ablation catheter increased the rate of acute real\u2010time recordings of pulmonary vein isolation (PVI) during the ablation for the treatment of atrial fibrillation (AF). The aim of this analysis was to compare the long\u2010term outcome results between patients treated with the CB4 and second\u2010generation cryoballoon (CB2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 492 patients suffering from AF, underwent PVI ablation with either the CB2 or CB4 catheter within this examination of the 1STOP real\u2010world Italian project and were included in the analysis. Specifically, 246 consecutive patients treated by CB4 were compared to 246 propensity\u2010matched control patients who underwent PVI using CB2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When comparing the patient cohorts treated with CB2 versus CB4, acute success rate (99.6 \u00b1 4.7%\u00a0vs. 99.7 \u00b1 3.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.949) and peri\u2010procedural complications (3.7%\u00a0vs.1.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.080) were similar in both groups, respectively. However, procedure time (100\u00a0vs.75\u00a0min, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and fluoroscopy duration (21\u00a0vs.17\u00a0min, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) were all significantly lower in the CB4 treated patient cohort. At the 12\u2010month follow\u2010up, the freedom from AF recurrence after a 90\u2010day blanking period was significant higher in the CB4 as compared with the CB2 group (93.3%\u00a0vs.81.3%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In summary, usage of the CB4 ablation catheter increased the rate of acute PVI recording capability and resulted in a higher rate of long\u2010term PVI success, as demonstrated by the reduced rate of AF recurrence in comparison to the CB2 cohort at the 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14494","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:00:24Z","timestamp":1649854824000},"page":"968-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Second versus fourth generation of cryoballoon catheters: The 1STOP real\u2010world multicenter experience"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-8850","authenticated-orcid":false,"given":"Massimiliano","family":"Manfrin","sequence":"first","affiliation":[{"name":"Ospedale San Maurizio  Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-4507","authenticated-orcid":false,"given":"Roberto","family":"Verlato","sequence":"additional","affiliation":[{"name":"ULSS 6 Euganea Ospedale di Cittadella\u2010Camposampiero  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Arena","sequence":"additional","affiliation":[{"name":"Ospedale delle Apuane  Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pieragnoli","sequence":"additional","affiliation":[{"name":"Ospedale Careggi University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Molon","sequence":"additional","affiliation":[{"name":"IRCCS Sacro Cuore don Calabria  Negrar Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-8313","authenticated-orcid":false,"given":"Claudio","family":"Tondo","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Department of Clinical Electrophysiology &amp; Cardiac Pacing Monzino Cardiac Center IRCCS Dept. of Biochemical Surgical and Dentist Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Perego","sequence":"additional","affiliation":[{"name":"Ospedale San Luca Istituto Auxologico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rovaris","sequence":"additional","affiliation":[{"name":"ASST San Gerardo di Monza  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-1330","authenticated-orcid":false,"given":"Luigi","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Policlinico Casilino  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mantica","sequence":"additional","affiliation":[{"name":"Centro Aritmie\u2010Istituto Clinico Sant' Ambrogio  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Sacchi","sequence":"additional","affiliation":[{"name":"Ospedale di Vimercate  Vimercate Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Campus Biomedico  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9388-3292","authenticated-orcid":false,"given":"Massimiliano","family":"Marini","sequence":"additional","affiliation":[{"name":"Ospedale Santa Chiara  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital GVM Care &amp; 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