{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:09:18Z","timestamp":1790017758897,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tachycardia\u2010induced cardiomyopathy is poorly recognized pre\u2010ablation. It remains unclear of better patient selection and timing for catheter ablation in persistent atrial fibrillation (PerAF) with heart failure (HF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with PerAF and left ventricular ejection fraction (LVEF)\u00a0&lt;50% referred for AF ablation were retrospectively included. The impact of LV size, heart rate (HR), and LVEF pre\u2010ablation were analyzed for assessing LV systolic function recovery, defined as LVEF increase of \u226520% or to a value \u226555% after ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 120 patients (2017\u20132020) were included. After 19 \u00b114 months post ablation, LVEF improvement was similar in patients with normal or dilated LV (18.3 \u00b1 9.4% vs. 16.1 \u00b1 10.8%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.25), rapid or controlled HR (19.5 \u00b1 10% vs. 16.1 \u00b1 10%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.09), but higher in HFrEF (HF with reduced EF) than HFmrEF (HF with midrange EF) (21.6 \u00b1 10.3% vs. 14.9 \u00b1 9.3%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01). There was more LV systolic function recovery in those with normal to moderate LV dilation (80%, odds ratio [OR] 15.22, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01), HR \u226580\u00a0bpm (79%, OR 5.38, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01) and HFmrEF (80%, OR 4.03, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.01). The overall AF freedom was similar between normal and dilated LV (59%\u00a0vs. 62%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.95), rapid and controlled HR (67%\u00a0vs. 56%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.18), and HFmrEF and HFrEF (65% vs. 50%, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Catheter ablation is effective independent of LV dilation, rate control or HFrEF. Patients with normal to moderate LV dilation, resting HR \u226580\u00a0bpm and HFmrEF may be candidates for early PerAF ablation to achieve LVEF normalization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14507","type":"journal-article","created":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T08:10:00Z","timestamp":1650183000000},"page":"629-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Catheter ablation for persistent atrial fibrillation with left ventricular systolic dysfunction: Who is the best candidate?"],"prefix":"10.1111","volume":"45","author":[{"given":"Lu","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou 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