{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:20:20Z","timestamp":1790727620218,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Right ventricular pacing (RVP) induces abnormal electrical activation and asynchronous ventricular contraction and leads to pacing induced cardiomyopathy (PICM) in 10%\u201320% of patients. Cardiac resynchronization therapy (CRT) utilizing biventricular pacing (BVP) is the recommended treatment. Left bundle branch pacing (LBBP) is a novel physiological pacing technique which may serve as an alternative to CRT. This study assessed feasibility and outcomes of LBBP delivered CRT in patients with PICM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Total 20 consecutive patients with PICM who received an upgrade of their pacemaker to LBBP were prospectively studied. Acute success rate, complications, functional and echocardiographic response, and hospitalization for heart failure within 6 months from implantation were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LBBP was successfully delivered in all patients. Median duration of RVP before upgrade to LBBP was 3.8 years and the RVP was 99%. LBBP resulted in significant QRS narrowing (from 193 \u00b1 18\u00a0ms to 130 \u00b1 17\u00a0ms [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001]), improvement in LVEF (from 32% \u00b1 6 % to 47% \u00b1 8% [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001]) and NYHA class (from 2.8 \u00b1 0.4 to 1.4 \u00b1 0.5 [<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001]) at 6 months. No LBBP\u2010related complications occurred. No patients were hospitalized for heart failure or died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LBBP is feasible and safe in delivering CRT in PICM. Preliminary analyses demonstrated significant electrical resynchronization and favorable improvement in LV function and NYHA functional class at short term follow\u2010up. Data needs to be validated in large randomized controlled trials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14515","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T12:23:23Z","timestamp":1651753403000},"page":"726-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Feasibility, safety and outcomes of upgrading to left bundle branch pacing in patients with right ventricular pacing induced cardiomyopathy"],"prefix":"10.1111","volume":"45","author":[{"given":"Leonard M.","family":"Rademakers","sequence":"first","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd","family":"Bouwmeester","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Mast","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Houthuizen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Bracke","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80140-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.00484.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2010.01804.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118974"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00757-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000072769.17295.B1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.24.3115"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.05.040"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.09.027"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.05.196"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz584"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.05.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp074"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.12.031"},{"issue":"7","key":"e_1_2_7_16_1","first-page":"1178","article-title":"Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function","volume":"19","author":"Jones S","year":"2017","journal-title":"Europace"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.09.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.04.037"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14628"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.06.016"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.08.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.013"},{"issue":"5","key":"e_1_2_7_25_1","first-page":"258","article-title":"Initial experience, feasibility and safety of permanent left bundle branch pacing: results from a prospective single\u2010centre study","volume":"30","author":"Rademakers LM","year":"2022","journal-title":"Initial experience, feasibility and safety of permanent left bundle branch pacing: results from a prospective single\u2010centre study. 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