{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:55:15Z","timestamp":1785416115515,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cryoballoon ablation (CBA) is one of the most commonly used technologies designed for pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF), although the dosing of CBA remains controversial. We evaluated the long\u2010term efficacy and safety of a novel individualized strategy of CBA compared to radiofrequency ablation (RFA) for patients with PAF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this observational study, symptomatic patients with drug\u2010refractory paroxysmal AF were prospectively consented and enrolled in four centers, being assigned either to the CBA or RFA arm for ablation. In the CBA group, we used a time to isolation (TTI) \u2013 based dosing protocol. The primary endpoint was the recurrence of atrial arrhythmia &gt;30 s following a 90\u2010day blanking period. The secondary endpoint was procedure\u2010related complications and procedure parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 500 patients were recruited in either the CBA group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0247) or the RFA group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0253) between January 2017 and July 2018. After a median follow\u2010up of 778 days, the atrial tachyarrhythmia\u2010free survival was 71.7% in the CBA group and 67.0% in the RFA group. CBA and RFA displayed similar major or minor complication occurrence, while the former had a significantly shorter procedure duration (82.5\u00a0min vs. 141.1\u00a0min, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and left atrial dwell time (60.1\u00a0min vs. 109.9\u00a0min, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) but longer fluoroscopy exposure (13.8\u00a0min vs. 8.1\u00a0min, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared to RFA, our TTI\u2010based CBA dosing protocol showed comparable efficacy and safety, with a significantly reduced procedure duration in patients with PAF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14556","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:09:15Z","timestamp":1656522555000},"page":"1015-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long\u2010term outcomes of a time to isolation \u2013 based strategy for cryoballoon ablation compared to radiofrequency ablation in patients with symptomatic paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"45","author":[{"given":"Yue","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fujian Provincial Hospital  Fuzhou People's Republic of 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