{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:13:48Z","timestamp":1775632428237,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Right ventricular (RV) dysfunction has been linked to a poor response to cardiac resynchronization therapy (CRT). We sought to determine whether cardiovascular magnetic resonance (CMR)\u2010derived measures of RV function influence clinical outcomes after CRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we used CMR to assess pre\u2010implant RV volumes and RV ejection fraction (RVEF) in relation to clinical outcomes after CRT implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 243 patients (age: 70.3\u00a0\u00b1\u00a010.8 years [mean\u00a0\u00b1 SD]; 68.7% male; 121 [49.8%]) with ischemic cardiomyopathy and 122 (50.2%)\u00a0with nonischemic cardiomyopathy, 141 (58%) after CRT\u2010defibrillation (CRT\u2010D) and 102 (42%) after CRT\u2010pacing (CRT\u2010P), 101 (41.6.0%) patients died, 61 (25.1%) from cardiac causes and 24 (9.88%) from noncardiac causes, over 5.87 years (median; interquartile range: 4.35\u20137.73). Two (0.82%) patients underwent cardiac transplantation and four (1.64%) had a left ventricular assist device (LVAD). A total of 41 (16.9%) met the composite endpoint of sudden cardiac death (SCD), ventricular tachycardia, or ventricular fibrillation. In univariate analyses, no measure of RV function was associated with total mortality or the arrhythmic endpoint. RVEF was associated with cardiac mortality on univariate analyses (HR per 10%: 0.82, 95% CI 0.70\u20130.96), but not on multivariate analyses that included left ventricular ejection fraction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no relationship between measures of RV function, such as RV volumes and RVEF, and the long\u2010term clinical outcome of CRT. These findings indicate that such measures should not be considered in patient selection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14572","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T10:09:04Z","timestamp":1659002944000},"page":"1075-1084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Right ventricular function and long\u2010term clinical outcomes after cardiac resynchronization therapy: A cardiovascular magnetic resonance study"],"prefix":"10.1111","volume":"45","author":[{"given":"Abbasin","family":"Zegard","sequence":"first","affiliation":[{"name":"Aston Medical School Aston University  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osita","family":"Okafor","sequence":"additional","affiliation":[{"name":"Aston Medical School Aston University  Birmingham 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