{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:09:17Z","timestamp":1771466957194,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Debates exist in the repeat ablation strategy for patients with recurrence presenting as persistent atrial fibrillation (AF) after initial persistent AF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the outcome between the \u201c2C3L\u201d and \u201cextensive ablation\u201d approach in patients undergoing repeat procedures for recurrent persistent AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Propensity\u2010score matching was performed in 196 patients with AF recurrence undergoing repeat ablation, and 79 patients treated with \u201c2C3L\u201d strategy were matched to 79 patients treated with \u201cextensive ablation\u201d strategy. The \u201c2C3L\u201d approach included pulmonary vein isolation, mitral isthmus, left atrial roof, and cavotricuspid isthmus ablation, while the \u201cextensive ablation\u201d strategy included extensive ablation of a variety of other targets aiming to terminate the AF. The primary outcome was freedom from any atrial tachyarrhythmia after 24\u2010h ambulatory monitoring follow\u2010up for 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant difference was found between the primary outcome between the \u201c2C3L\u201d and the \u201cextensive ablation\u201d group [70.9%\u00a0vs. 69.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.862; 95% confidence interval (CI) \u201012.8 to 15.3], although the \u201cextensive ablation\u201d group had a significantly high proportion of AF termination (19.0% for \u201c2C3L\u201d vs. 41.8% for \u201cextensive ablation\u201d group, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002; 95% CI 8.5\u201335.9). And AF termination was not related to the primary outcome in multifactorial regression. At 40\u00a0\u00b1\u00a022 months after the repeat procedure, the primary outcome was also comparable (57.0 % for \u201c2C3L\u201d vs. 48.1% for \u201cextensive ablation\u201d group, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.265; 95% CI \u20106.6 to 23.7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The outcome between the \u201c2C3L\u201d and \u201cextensive ablation\u201d approaches was comparable in patients undergoing repeat procedures for recurrent persistent AF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14595","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T15:28:03Z","timestamp":1663342083000},"page":"1349-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repeat ablation strategy for recurrent persistent atrial fibrillation: A propensity\u2010matched score comparison between \u201c2C3L\u201d and \u201cextensive ablation\u201d approach"],"prefix":"10.1111","volume":"45","author":[{"given":"Jing","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-0589","authenticated-orcid":false,"given":"Chen\u2010Xi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases Beijing Advanced Innovation Center for Big Data\u2010Based Precision Medicine for Cardiovascular Diseases  Beijing 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