{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:24:46Z","timestamp":1779931486925,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The implantable cardioverter defibrillator (ICD) has been demonstrated to successfully prevent sudden cardiac death (SCD) in children and young adults. A wide range of device\u2010related complications\/malfunctions have been described, which depend on the intrinsic design of the defibrillation system (transvenous\u2010implantable cardioverter defibrillator [TV\u2010ICD] vs. subcutaneous\u2010implantable cardioverter defibrillator [S\u2010ICD]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the device\u2010related complications and inappropriate shocks with TV\u2010ICD versus S\u2010ICD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Electronic databases were queried for studies focusing on the prevention of SCD in children and young adults with TV\u2010ICD or S\u2010ICD. The effect size was estimated using a random\u2010effect model as odds ratio (OR) and relative 95% confidence interval (CI). The primary endpoint was a composite of any device\u2010related complications and inappropriate shocks. We identified a total of five studies including 236 patients (Group S\u2010ICD: 76 patients; Group TV\u2010ICD: 160 patients) with a mean follow\u2010up time of 54.2\u00a0\u00b1\u00a024.9\u00a0months. S\u2010ICD implantation contributed to a significant reduction in the risk of the primary endpoint of any device\u2010related complications and inappropriate shocks (OR: 0.18; 95% CI: 0.05\u20130.73; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). S\u2010ICD was also associated with a significantly lower incidence of inappropriate shocks (OR: 0.28; 95% CI: 0.11\u20130.74; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) and lead\u2010related complications (OR: 0.18; 95% CI: 0.05\u20130.66; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). A trend toward a higher risk of pocket complications (OR: 5.91; 95% CI: 0.98\u201335.63; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.05) was recorded in patients with S\u2010ICD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Children and young adults undergoing S\u2010ICD implantation may have a lower risk of a composite of device\u2010related complications and inappropriate shocks, compared to TV\u2010ICD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14603","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T13:49:31Z","timestamp":1665409771000},"page":"1409-1414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Subcutaneous versus transvenous implantable cardioverter defibrillators in children and young adults: A meta\u2010analysis"],"prefix":"10.1111","volume":"45","author":[{"given":"Giampaolo","family":"Vetta","sequence":"first","affiliation":[{"name":"Cardiology Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-6053","authenticated-orcid":false,"given":"Antonio","family":"Parlavecchio","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-0114","authenticated-orcid":false,"given":"Michele","family":"Magnocavallo","sequence":"additional","affiliation":[{"name":"Cardiology Division, Arrhythmology Unit S. Giovanni Calibita Hospital  Isola Tiberina Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Valente","sequence":"additional","affiliation":[{"name":"Maternal\u2010Infantile and Urological Science Department \u201cSapienza\u201d University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Polselli","sequence":"additional","affiliation":[{"name":"Cardiology Division, Arrhythmology Unit S. Giovanni Calibita Hospital  Isola Tiberina Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vetta","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit Paideia Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatello","family":"Cirone","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero\u2010Universitaria Careggi  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2088-8070","authenticated-orcid":false,"given":"Filippo Maria","family":"Cauti","sequence":"additional","affiliation":[{"name":"Cardiology Division, Arrhythmology Unit S. Giovanni Calibita Hospital  Isola Tiberina Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Crea","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Rossi","sequence":"additional","affiliation":[{"name":"Cardiology Division, Arrhythmology Unit S. Giovanni Calibita Hospital  Isola Tiberina Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Battista","family":"Chierchia","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel\u2010Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Cardiology Division, Arrhythmology Unit S. Giovanni Calibita Hospital  Isola Tiberina Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"de Asmundis","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel\u2010Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Natale","sequence":"additional","affiliation":[{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Giovanni","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel\u2010Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"},{"name":"Texas Cardiac Arrhythmia Institute St. David's Medical Center  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.03.552"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57030205"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12878"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus388"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.33963\/KP.15469"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12233"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12471\u2010018\u20101186\u20101"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9020033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12878"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.001569"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy139"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108167.2011.02199.x"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.14603","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:08:20Z","timestamp":1692508100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/pace.14603"],"URL":"https:\/\/doi.org\/10.1111\/pace.14603","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"2022-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}