{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:35:41Z","timestamp":1757705741350,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Conventional right ventricular pacing combined with coronary venous pacing (CVP) is a mainstay for cardiac resynchronization therapy (CRT). However, QRS duration of conventional CRT may be frequently more than 130\u00a0ms. This study aimed to evaluate the effectiveness of QRS narrowing by bilateral septal pacing (BSP) in combination with CVP for CRT (BSP\u2010CRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fourteen patients with QRS\u00a0&gt;\u00a0130\u00a0ms of conventional CRT after failure of physiological conduction system pacing were enrolled. Electrophysiologic characteristics were compared among different modes of CRT during procedure. BSP which was defined as capture of both sides of interventricular septum manifested as shortened R wave peak time without a right bundle branch block QRS pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BSP\u2010CRT were successfully achieved in 85.7% (12\/14) patients. QRS duration at baseline was 185\u00a0\u00b1\u00a013\u00a0ms and significantly narrowed to 156\u00a0\u00b1\u00a09\u00a0ms during conventional CRT (n\u00a0=\u00a014, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), to 143\u00a0\u00b1\u00a07\u00a0ms during left ventricular septal pacing (LVSP) in combination with CVP for CRT (LVSP\u2010CRT) (n\u00a0=\u00a09, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and further to 122\u00a0\u00b1\u00a010\u00a0ms during BSP\u2010CRT (n\u00a0=\u00a012, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Notably, among 7 patients in whom both LVSP and BSP were achieved, BSP\u2010CRT outperformed LVSP\u2010CRT at QRS narrowing by 16% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). At 3\u2010month follow\u2010up, left ventricular ejection fraction improved from 29\u00a0\u00b1\u00a06% to 41\u00a0\u00b1\u00a08% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BSP\u2010CRT resulted in superior acute electrical synchronization to conventional CRT and might be considered as an alternative to conventional CRT with QRS more than 130\u00a0ms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14628","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T12:31:46Z","timestamp":1669293106000},"page":"226-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bilateral septal pacing in combination with coronary venous pacing for cardiac resynchronization therapy"],"prefix":"10.1111","volume":"46","author":[{"given":"Jialin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baige","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4719-0564","authenticated-orcid":false,"given":"Zulu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Northern Theater Command  Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2158-0158","authenticated-orcid":false,"given":"Yanchun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology General 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