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Unlike other cardiological disorders, a definite etiology has not yet been established so that it could be summarized under two main chapters: \u201cfunctional\u201d or \u201corganic\u201d, \u201crepolarization\u201d or \u201cdepolarization\u201d disorder. Despite initial descriptions leaned towards the organic substrate and delayed depolarization features, functional and repolarization theories have attracted most of the Cardiological attention for many years. Data from electrocardiography, endocavitary tracings, electroanatomic mapping and histopathology, however, demonstrated that BrS is mainly characterized by structural myocardial changes mostly at the right ventricular outflow tract (RVOT), but also at the right ventricle (RV) and by delayed conduction at the same sites. Conduction disorders at different levels may also be present and identify patients at high risk for major arrhythmic events. The aim of the present review is to provide the current state of art of the pathophysiology of BrS, focusing on electro\u2010vectorcardiography and electrophysiological features, histopathology, echocardiography, and cardiac magnetic resonance imaging (CMRI).<\/jats:p>","DOI":"10.1111\/pace.14650","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T16:50:01Z","timestamp":1671641401000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Delayed depolarization and histologic abnormalities underlie the Brugada syndrome"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1935-0484","authenticated-orcid":false,"given":"Bortolo","family":"Martini","sequence":"first","affiliation":[{"name":"Cardiac Unit Alto Vicentino Hospital  Santorso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"De Mattia","sequence":"additional","affiliation":[{"name":"Cardiac Unit Ca\u2019 Foncello Hospital  Treviso Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Buja","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Thoraco\u2010Vascular Sciences and Public Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195322650-00011"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90253-J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.2.372"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.01.067"},{"key":"e_1_2_10_6_1","first-page":"157","article-title":"La repolarisation precoce dans les precordiales droites: trouble de la conduction intraventriculaire droite? 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