{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:56:15Z","timestamp":1787075775655,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to investigate the feasibility and effectiveness of transthoracic epicardial dual\u2010chamber pacemaker implantation in the treatment of cardiac dysfunction caused by idiopathic complete left bundle branch block (CLBBB) in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nine children diagnosed with cardiac dysfunction due to idiopathic CLBBB were included in this study. All patients underwent transthoracic epicardial dual\u2010chamber pacemaker implantation. Cardiac function was evaluated using echocardiography during the follow\u2010up. Additionally, intraventricular synchronization parameters were assessed using two\u2010dimensional speckle tracking echocardiography (STE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine children (mean age, 3.0\u00a0\u00b1\u00a02.6 years) were included in this study. The median follow\u2010up duration was 2 (interquartile range, 1\u20133) years. The cardiac function of all patients recovered to normal levels within 1 year postoperatively. The postoperative QRS duration on electrocardiography (142\u00a0\u00b1\u00a021\u00a0ms) was significantly shorter than that at baseline (106\u00a0\u00b1\u00a012\u00a0ms) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Cardiac dyssynchrony in patients who manifested preoperatively achieved complete correction after pacemaker implantation. The comparison of preoperative and postoperative (last follow\u2010up visit) synchronization parameters were as follows: longitudinal standard deviation of the time to peak strain, 99.0\u00a0\u00b1\u00a041.9 versus 36.8\u00a0\u00b1\u00a05.0\u00a0ms (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004); delay time of peak longitudinal strain, 252.2\u00a0\u00b1\u00a0131.4 versus 35.0\u00a0\u00b1\u00a022.9\u00a0ms (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002); and longitudinal systolic dyssynchrony index, 2.8\u00a0\u00b1\u00a00.8% versus 1.0\u00a0\u00b1\u00a00.3% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transthoracic epicardial dual\u2010chamber pacemaker implantation (with left atrial sensing and left ventricular single\u2010site pacing) can be used for the treatment of cardiac dysfunction caused by idiopathic CLBBB in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14652","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T10:38:20Z","timestamp":1672051100000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Left ventricular pacing in the treatment of pediatric cardiac dysfunction caused by idiopathic complete left bundle branch block"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-8913","authenticated-orcid":false,"given":"Xiaomei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing China"},{"name":"School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2608-1606","authenticated-orcid":false,"given":"Jinghao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing China"},{"name":"School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-6242","authenticated-orcid":false,"given":"He","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing China"},{"name":"School of Clinical Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Heart Center the First Hospital of Tsinghua University (Beijing Huaxin Hospital)  Beijing 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