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However, the exact etiology of this disease remains poorly understood. Recent studies found disorders of iron metabolism might be involved in the progression of AF. Abnormal iron metabolism in cardiomyocytes provides arrhythmogenic substrates through a variety of mechanisms, including calcium mishandling, ion channel remodeling, and oxidative stress overaction. Interestingly, in AF patients with iron overload, interventions on iron metabolism, such as iron chelators and ferroptosis inhibitors, has been shown to prevent AF via reducing ferroptosis. Herein, we review the possible mechanisms, consequences, and therapeutic implications of altered atrial iron handling for AF pathophysiology.<\/jats:p>","DOI":"10.1111\/pace.14678","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T10:54:30Z","timestamp":1676631270000},"page":"312-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Iron and atrial fibrillation: A review"],"prefix":"10.1111","volume":"46","author":[{"given":"Hao","family":"Ju","sequence":"first","affiliation":[{"name":"Department of Cardiology Remin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Remin Hospital of Wuhan University  Wuhan 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