{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:57:08Z","timestamp":1793120228538,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy (CRT) reduces heart failure (HF) hospitalization and all\u2010cause mortality in HF patients with left bundle branch block (LBBB). Biventricular pacing (BVP) is the gold standard for achieving CRT, but about 30%\u201340% of patients do not respond to BVP\u2010CRT. Recent studies showed that left bundle branch pacing (LBBP) provided remarkable results in CRT. Therefore, we conducted a meta\u2010analysis aiming to compare LBBP\u2010CRT versus BVP\u2010CRT in HF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched the electronic databases for studies published from inception to December 29, 2022 and focusing on LBBP\u2010CRT versus BVP\u2010CRT in HF patients. The primary endpoint was HF hospitalization. The effect size was estimated using a random\u2010effect model as Risk Ratio (RR) and mean difference (MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten studies enrolling 1063 patients met the inclusion criteria. Compared to BVP\u2010CRT, LBBP\u2010CRT led to significant reduction in HF hospitalization [7.9%\u00a0vs.14.5%; RR: 0.60 (95%CI: 0.39\u20130.93);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02], QRSd [MD: 30.26\u00a0ms (95%CI: 26.68\u201333.84);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001] and pacing threshold [MD: \u22120.60 (95%CI: \u22120.71 to \u22120.48);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001] at follow up. Furthermore, LBBP\u2010CRT improved LVEF [MD: 5.78% (95%CI: 4.78\u20136.77);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001], the rate of responder [88.5%\u00a0vs.72.5%; RR: 1.19 (95%CI: 1.07\u20131.32);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.002] and super\u2010responder [60.8%\u00a0vs. 36.5%; RR: 1.56 (95%CI: 1.27\u20131.91);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001] patients and the NYHA class [MD: \u22120.42 (95%CI: \u22120.71 to \u22120.14);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.00001] compared to BVP\u2010CRT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In HF patients, LBBP\u2010CRT was superior to BVP\u2010CRT in reducing HF hospitalization. Further significant benefits occurred within the LBBP\u2010CRT group in terms of QRSd, LVEF, pacing thresholds, NYHA class and the rate of responder and super\u2010responder patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.14700","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T13:09:46Z","timestamp":1681132186000},"page":"432-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Left bundle branch pacing versus biventricular pacing for cardiac resynchronization therapy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7122-6053","authenticated-orcid":false,"given":"Antonio","family":"Parlavecchio","sequence":"first","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-0492","authenticated-orcid":false,"given":"Giampaolo","family":"Vetta","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Coluccia","sequence":"additional","affiliation":[{"name":"Cardiology Unit Card. 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Panico Hospital Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Magnocavallo","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit Ospedale San Giovanni Calibita Fatebenefratelli Isola Tiberina  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Ajello","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pistelli","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Dattilo","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Foti","sequence":"additional","affiliation":[{"name":"San Vincenzo Hospital  Taormina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scipione","family":"Carerj","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico Giovanni","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and Pacing Universitair Ziekenhuis Brussel\u2010Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Crea","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Cardiology Unit Card. 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