{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:34:27Z","timestamp":1788489267188,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study is intended to evaluate the acute and long\u2010term effectiveness and peri\u2010procedural safety in ablation of persistent atrial fibrillation (PsAF) using the CartoFinder algorithm guided ablation (CFGA) targeting on repetitive activation patterns (RAPs) and focal impulses (FIs) identified in dynamic maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective, single\u2010arm, multicenter study. A 64\u2010pole multielectrode basket catheter was used for intracardiac global electrogram (EGM) mapping. The RAPs or FIs were repeatedly mapped and ablated for up to five iterations by the CartoFinder algorithm to achieve sinus rhythm (SR) or organized atrial tachycardia (AT), which were followed by PVI. All patients were followed up for 12 months after procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four PsAF patients (age, 60.7\u00a0\u00b1\u00a09.1\u00a0years; male, 76.6%; median PsAF duration, 6.0 months) underwent CFGA on RAPs\/FIs. Six patients (9.4%) reported primary adverse event (PAE) including groin hematoma (2), complete heart block (1), tamponade (1), pericarditis (1), and pseudoaneurysm (1). Repeated mapping and ablation on RAPs\/FIs resulted in the cycle length (CL) increase from 191.0\u00a0\u00b1\u00a0167.6\u00a0ms at baseline to 365.7\u00a0\u00b1\u00a0296.7\u00a0ms in the LA and from 167.8\u00a0\u00b1\u00a041.6\u00a0ms to 379.4\u00a0\u00b1\u00a0293.5\u00a0ms in the RA and 30.2% (19\/63) AF termination to SR or organized AT. The 12\u2010month arrhythmia\u2010free and symptomatic AF\u2010free rates were 60.9% and 75.0%, respectively. Patients with acute AF termination showed a higher 12\u2010month arrhythmia\u2010free rate (76.9%) than those without (50.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study demonstrated that the CartoFinder algorithm can be used for global activation mapping during PsAF ablation. Patients with acute AF termination had a lower 12\u2010month AF recurrence rate compared to patients without.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14708","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T07:03:30Z","timestamp":1684566210000},"page":"729-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Safety and efficacy of catheter ablation on patients with persistent atrial fibrillation by targeting repetitive activation patterns and focal impulses"],"prefix":"10.1111","volume":"46","author":[{"given":"Tom","family":"de Potter","sequence":"first","affiliation":[{"name":"Cardiology Department OLV Hospital  Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sarkozy","sequence":"additional","affiliation":[{"name":"Cardiology Department Universitair Ziekenhuis Antwerpen  Edegem Belgium"},{"name":"University of Antwerp  Antwerpen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Duytschaever","sequence":"additional","affiliation":[{"name":"Cardiology Department AZ Sint Jan  Bruges Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bulava","sequence":"additional","affiliation":[{"name":"Ceske Budejovice Hospital  Ceske Budejovice Czech Republic"},{"name":"Faculty of Health and Social Sciences University of South Bohemia in Ceske Budejovice  Ceske Budejovice Czech 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