{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T09:06:32Z","timestamp":1793523992898,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Catheter ablation for non\u2010paroxysmal atrial fibrillation (non\u2010PAF) remains challenging and more effective strategy has been required to reduce postoperative arrhythmia recurrences. This study aims to investigate the efficacy and safety of a novel extensive ablation strategy for non\u2010PAF, that is based on a combination of cryoballoon (CBA), radiofrequency (RFA), and Marshall\u2010vein ethanol ablations (EA\u2010VOM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a single\u2010center, retrospective observational study. We enrolled 171 consecutive patients who underwent de\u2010novo catheter ablation for non\u2010PAF under conscious sedation with a novel extensive ablation strategy that included CBA for pulmonary vein isolation (PVI) and left atrial roof ablation (LARA), RFA for mitral isthmus (MI) ablation, superior vena cava isolation, and other linear ablations and EA\u2010VOM. Recurrence of atrial arrhythmias over 1\u00a0year, procedure outcomes, and procedure\u2010related complications were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 139 (81.3%) patients remained in sinus rhythm during 1\u2010year follow\u2010up. Of the 139 patients, 51 patients (29.8%) received antiarrhythmic drugs. The mean procedure time was 204\u00a0\u00b1\u00a045\u00a0min. PVI and LARA ablation by CBA and MI block by RFA and EA\u2010VOM were completed in 171 (100%) and 166 (97.1%) patients, respectively. No serious procedure\u2010related complications were observed except for one case of delayed pericardial effusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately 80% of the study patients were AF\u2010free during 1\u2010year follow\u2010up period after a single procedure based on the novel extensive ablation strategy combining CBA, RFA, and EA\u2010VOM. This strategy for non\u2010PAF may be preferred in terms of maintenance of sinus rhythm, safety even in high\u2010risk patients, and relatively short procedure time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14709","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T11:24:16Z","timestamp":1683026656000},"page":"475-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A novel catheter ablation strategy for non\u2010paroxysmal atrial fibrillation combining cryoballoon, radiofrequency, and Marshall\u2010vein ethanol ablations"],"prefix":"10.1111","volume":"46","author":[{"given":"Kazuto","family":"Hayasaka","sequence":"first","affiliation":[{"name":"Heart Rhythm Center National Hospital Organization Disaster Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5085-0810","authenticated-orcid":false,"given":"Takeshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center National Hospital Organization Disaster Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-2797","authenticated-orcid":false,"given":"Yasuhiro","family":"Shirai","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center National Hospital Organization Disaster Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Shimosato","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center National Hospital Organization Disaster Medical Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Tahara","sequence":"additional","affiliation":[{"name":"Heart 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