{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:50:44Z","timestamp":1747187444657,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) guidelines recommend amiodarone as the preferred antiarrhythmic medication (AAM) in patients with left ventricular hypertrophy (LVH), due to potential pro\u2010arrhythmic risk with other AAM. However, there are limited data to support this assertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the records of 8204 patients who were prescribed AAM for AF and had transthoracic echocardiogram (TTE) at the multicenter, VA Midwest Health Care Network from 2000 to 2021. We excluded patients without LVH (septal or posterior wall dimension\u00a0\u22641.4\u00a0cm). The primary outcome variable was all\u2010cause mortality during antiarrhythmic therapy or within 6 months after stopping it. Propensity\u2010stratified analyses were performed between amiodarone versus non\u2010amiodarone (Vaughan\u2010Williams Class I and III) AAM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1277 patients with LVH (mean age 70.2\u00a0\u00b1\u00a09.5 years) were included in the analysis. Of these, 774 (60.6%) were prescribed amiodarone. Baseline characteristics of the two comparison groups were similar after propensity adjustment. After a median 1.40 years of follow\u2010up, 203 (15.9%) patients died. Incidence rates per 100 patient\u2010year follow\u2010up was 9.02 (7.58\u201310.66) for amiodarone and 4.98 (3.91\u201362.56) for non\u2010amiodarone. In propensity\u2010stratified analysis, amiodarone use was associated with 1.58 times higher risk of mortality (95% CI 1.03\u20132.44; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.038). Sub\u2010group analysis in 336 (26.3%) patients with severe LVH showed no difference in mortality (HR 1.41, 95% CI 0.82\u20132.43, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.21).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among patients with AF and LVH, amiodarone was associated with a significantly higher mortality risk than other AAM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14711","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T21:27:04Z","timestamp":1683754024000},"page":"738-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality associated with antiarrhythmic medication for atrial fibrillation among patients with left ventricular hypertrophy"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0271-6338","authenticated-orcid":false,"given":"Arianne Clare","family":"Agdamag","sequence":"first","affiliation":[{"name":"Departments of Cardiology, Pharmacy and Research Minneapolis VA Health Care System  Minneapolis Minnesota USA"},{"name":"Lillehei Heart Institute and Cardiovascular Division, Department of Medicine University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Westanmo","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Pharmacy and Research Minneapolis VA Health Care System  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Gravely","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Pharmacy and Research Minneapolis VA Health Care System  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natthapon","family":"Angsubhakorn","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Pharmacy and Research Minneapolis VA Health Care System  Minneapolis Minnesota USA"},{"name":"Lillehei Heart Institute and Cardiovascular Division, Department of Medicine University of Minnesota Medical School  Minneapolis Minnesota USA"},{"name":"Division of Cardiology Loma Linda University School of Medicine  Loma Linda California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin Yee","family":"Chen","sequence":"additional","affiliation":[{"name":"Lillehei Heart Institute and Cardiovascular Division, Department of Medicine University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2154-8596","authenticated-orcid":false,"given":"Selcuk","family":"Adabag","sequence":"additional","affiliation":[{"name":"Departments of Cardiology, Pharmacy and Research Minneapolis VA Health Care System  Minneapolis Minnesota USA"},{"name":"Lillehei Heart Institute and Cardiovascular Division, Department of Medicine University of Minnesota Medical School  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux373"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.05.060"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12426"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.3.234"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"volume-title":"VIReC Technical Report 2. 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