{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:17:34Z","timestamp":1764364654667,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation (AF) is a rapidly increasing global public health concern entailing a high risk for ischemic stroke that can largely be avoided with anticoagulation therapy. AF is often underdiagnosed and there is a need for a reliable method of detection in individuals with additional risk factors for stroke such as coronary artery disease. We aimed to validate an automatic rhythm interpretation algorithm in thumb ECG in subjects with recent coronary revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thumb ECG, a patient\u2010operated handheld single\u2010lead ECG recording device with an automatic interpretation algorithm, was performed three times daily for a month after coronary revascularization and 2\u2010week periods 3, 12, and 24 months post\u2010procedure. The detection of AF by the automatic algorithm on subject and single\u2010strip ECG level was compared to manual interpretation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>48,308 of 30 s thumb ECG recordings from 255 subjects (mean 212\u00a0\u00b1\u00a03.5 recordings per subject) were retrieved from a database (AF 47 subjects\/655 recordings; non\u2010AF 208 subjects\/47,653 recordings). The algorithm sensitivity at subject level was 100%, specificity 11.2%, positive predictive value (PPV) 20.2%, and negative predictive value (NPV) 100%. At the single\u2010strip ECG level, sensitivity was 87.6%, specificity 94.0%, PPV 16.8%, and NPV 99.8%. The most common reasons for false positive results were technical disturbance and frequent ectopic beats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The automatic interpretation algorithm in a handheld thumb ECG device can rule out AF in patients recently undergoing coronary revascularization with high accuracy, but manual confirmation is needed to confirm the diagnose of AF because of high false positive rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14745","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T07:21:10Z","timestamp":1684912870000},"page":"782-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of a handheld single\u2010lead ECG algorithm for atrial fibrillation detection after coronary revascularization"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-1167","authenticated-orcid":false,"given":"Sofia","family":"Skr\u00f6der","sequence":"first","affiliation":[{"name":"Centre for Clinical Research and Education Region V\u00e4rmland  Karlstad Sweden"},{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-8996","authenticated-orcid":false,"given":"Anders","family":"Wickbom","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  Sweden"},{"name":"Department of Cardiothoracic and Vascular Surgery \u00d6rebro University Hospital  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-3310","authenticated-orcid":false,"given":"Anna","family":"Bj\u00f6rkenheim","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  Sweden"},{"name":"Department of Cardiology \u00d6rebro University Hospital  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-0669","authenticated-orcid":false,"given":"Anders","family":"Ahlsson","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7618-4377","authenticated-orcid":false,"given":"Dritan","family":"Poci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  Sweden"},{"name":"Department of Clinical Physiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Molecular and Clinical Medicine, Institution for Medicine, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-9427","authenticated-orcid":false,"given":"Espen","family":"Fengsrud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Medical Sciences \u00d6rebro University  Sweden"},{"name":"Department of Cardiology \u00d6rebro University Hospital  \u00d6rebro Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019897870"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_11_4_1","first-page":"1449","article-title":"Safe automatic one\u2010lead electrocardiogram analysis in screening for atrial fibrillation","volume":"19","author":"Svennberg 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User Guide Doctor System 3.3 [pamphlet]. Stockholm: Zenicor Medical Systems AB;2018."}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:03:15Z","timestamp":1692309795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/pace.14745"],"URL":"https:\/\/doi.org\/10.1111\/pace.14745","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"assertion":[{"value":"2023-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}