{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T14:21:56Z","timestamp":1768314116439,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brain natriuretic peptide (BNP) is a marker of myocardial stretch and may have prognostic significance in patients with atrial fibrillation (AF) without heart failure (HF). We investigated the association between baseline BNP levels and arrhythmia recurrence following pulmonary vein isolation (PVI) among patients with persistent AF without HF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 125 patients with persistent AF without HF who had baseline BNP measured from the DECAAF II trial. The primary outcome was arrhythmia recurrence following ablation. The baseline characteristics across the two groups were compared using Chi\u2010square test and Wilcoxon rank test accordingly. Cox regression analysis was used to analyze the association between baseline BNP levels and the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across the entire cohort, 64 (51%) patients experienced arrhythmia recurrence. When comparing patients who experienced arrythmia recurrence to patients who did not, patients with recurrent arrhythmia had higher levels of pre\u2010ablation BNP, as evidenced by differences in means (330.05\u00a0pg\/mL) compared to patients without recurrent arrhythmia (182.39 pg\/mL) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). A cut\u2010off BNP value of 300\u00a0pg\/mL provided the largest area under curve (AUC) of receiver\u2010operating characteristic (ROC) curve on univariate logistic regression. On unadjusted Cox analysis, for every 100 unit increase in BNP, the hazard ratio for the primary outcome increased 1.09 (1.026\u20131.158) times (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). After adjusting for sex, hypertension, and stroke, the results remained significant (HR\u00a0=\u00a01.8516, CI 95% [1.0139 \u2013 3.381], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.045).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the non\u2010heart failure population, BNP levels predict AF recurrence following PVI in persistent AF patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14762","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T23:35:18Z","timestamp":1687649718000},"page":"848-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline natriuretic peptides as a predictor of atrial fibrillation recurrence after radiofrequency\u2010based pulmonary vein isolation in a non\u2010heart failure population: A subanalysis from DECAAF II"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-1164","authenticated-orcid":false,"given":"Hadi","family":"Younes","sequence":"first","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Mekhael","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Feng","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel","family":"Noujaim","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Chouman","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Assaf","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4820-8102","authenticated-orcid":false,"given":"Abdel\u2010Hadi el","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilas","family":"Dagher","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanho","family":"Lim","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitabh","family":"Pandey","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Kreidieh","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0454-0541","authenticated-orcid":false,"given":"Nassir","family":"Marrouche","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eoin","family":"Donnellan","sequence":"additional","affiliation":[{"name":"Tulane Research and Innovation for Arrhythmia Discoveries\u2010TRIAD Center Tulane University School of Medicine New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1454986"},{"key":"e_1_2_11_3_1","volume-title":"Natriuretic Peptide B Type Test","author":"Novack ML","year":"2022"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.132.5.8477647"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112723"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020233"},{"issue":"5","key":"e_1_2_11_7_1","first-page":"370","article-title":"B\u2010type natriuretic peptide, disease progression and clinical outcomes in atrial fibrillation","volume":"105","author":"Inohara T","year":"2019","journal-title":"Heart"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl109"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(23)00687-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2023.2172402"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"392","article-title":"Association of pre\u2010ablation level of potential blood markers with atrial fibrillation recurrence after catheter ablation: a meta\u2010analysis","volume":"19","author":"Jiang H","year":"2017","journal-title":"Europace"},{"key":"e_1_2_11_12_1","first-page":"241","article-title":"Predicting successful pulmonary vein isolation in patients with atrial fibrillation by brain natriuretic Peptide plasma levels","volume":"9","author":"Shin DI","year":"2009","journal-title":"Indian Pacing Electrophysiol 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