{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:56:49Z","timestamp":1787795809298,"version":"build-2784847793"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients undergoing cardiac resynchronization therapy using left bundle branch area pacing (LBBP\u2010CRT), the addition of a coronary sinus lead, that is, Left bundle optimized CRT (LOT\u2010CRT) might confer additional benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the electrocardiographic characteristics between LBBP\u2010CRT and LOT\u2010CRT<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with non\u2010ischemic cardiomyopathy (NICMP) and left bundle branch block (LBBB) with left ventricular ejection fraction\u00a0&lt;35% who underwent implantation of an atrial lead, a left bundle lead, and a coronary sinus lead were included in this prospective study. Digital 12\u2010lead electrocardiograms were recorded in three pacing modes\u2014AAI, DDD with pacing from the LBB lead (LBBP\u2010CRT), and DDD with pacing from both left bundle and coronary sinus leads (LOT\u2010CRT). QRS duration (QRSd), QRS area, QT interval, and T peak\u2013T end (TpTe) intervals were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 24 patients, QRSd reduced from 167\u00a0\u00b1\u00a021.2\u00a0ms to 134.5\u00a0\u00b1\u00a023.6\u00a0ms with LBBP\u2010CRT (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and 129.5\u00a0\u00b1\u00a018.6\u00a0ms with LOT\u2010CRT (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) without a significant difference between LBBP\u2010CRT and LOT\u2010CRT (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.15). Patients with QRS duration with LBBP\u2010CRT\u00a0&gt;\u00a0131\u00a0ms showed a significant reduction in QRSd with LOT\u2010CRT (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). QT interval was reduced with both modes of CRT. LOT\u2010CRT was associated with a greater reduction in QRS area (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), TpTe interval (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03), and TpTe\/QT ratio (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.013) compared to LBBP\u2010CRT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with NICMP and LBBB, there was no significant difference in QRSd with LOT\u2010CRT compared to LBBP\u2010CRT. However, in patients with QRSd\u00a0&gt;\u00a0131\u00a0ms after LBBP\u2010CRT, LOT\u2010CRT resulted in a significantly narrower QRS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14793","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T13:49:39Z","timestamp":1689947379000},"page":"840-847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of electrocardiographic parameters between left bundle optimized cardiac resynchronization therapy (LOT\u2010CRT) and left bundle branch pacing\u2014cardiac resynchronization therapy (LBBP\u2010CRT)"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-1940","authenticated-orcid":false,"given":"Chinmay","family":"Parale","sequence":"first","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5902-6972","authenticated-orcid":false,"given":"Dinakar","family":"Bootla","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-9177","authenticated-orcid":false,"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh","family":"Satheesh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Anantharaj","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Shaheer","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh Kumar","family":"Sukumaran","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Balaguru","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Cardiology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp368"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus340"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.07.019"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi146"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.07.057"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2021.26"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.02.021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab164"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/EHF2.12654"},{"key":"e_1_2_11_11_1","unstructured":"SelvarajR.An online XML ECG viewer. 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