{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:20:37Z","timestamp":1774416037513,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with chronic right ventricular (RV) pacing are at an increased risk of heart failure. Previous studies have indicated that cardiac resynchronization therapy (CRT) is underused in this setting, and that there may be sex\u2010based differences in both CRT use and clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate sex\u2010based differences in CRT use and clinical outcome for patients with new\u2010onset heart failure post RV pacing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Swedish pacemaker registry was matched with data from the national death and disease registries. Patients with de novo pacemaker implant due to AV block during the period 2005\u20132020 were included. New\u2010onset heart\u2010failure within two years post\u2010implant was evaluated, primary outcome was all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 30183 patients (37% female) were included. Women were on average 3 years older, but had less comorbidities than men. Median follow\u2010up time was 4.5 [2.0\u20138.0] years. Women had better age\u2010 and comorbidity\u2010adjusted survival (HR 0.78 [0.73\u20130.84], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). For the 3560 patients (12.4% men and 10.7% women, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) who were diagnosed with new\u2010onset heart failure, 5\u2010year mortality was similar for men and women (50%\u00a0vs. 48%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.29). However, women were less likely to receive CRT\u2010upgrade (3.8%\u00a0vs. 9.1%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), and those who did were almost ten years younger than the men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with pacemaker due to AV block are older but have less comorbidities than men. They are less likely to develop new\u2010onset heart failure, but also less likely to receive a CRT upgrade if they do develop heart failure. Increased awareness of the positive effects of CRT upgrade and potential sex\u2010 and age\u2010based discrimination is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14796","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:54:36Z","timestamp":1693230876000},"page":"1153-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sex\u2010based differences in cardiac resynchronization therapy upgrade and outcome for patients with pacemaker and new\u2010onset heart failure"],"prefix":"10.1111","volume":"46","author":[{"given":"Cecilia","family":"Rorsman","sequence":"first","affiliation":[{"name":"Cardiology Department of Clinical Sciences Lund University, Lund Sweden"},{"name":"Internal Medicine Department Varberg Hospital  Varberg 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