{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:24:17Z","timestamp":1788582257940,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intermittent ventricular pre\u2010excitation was considered a low\u2010risk marker for sudden death. However, to date, some studies do not exclude the existence of accessory pathways (APs) with high\u2010risk intermittent antegrade conductive properties. According to current European Guidelines, high\u2010risk features of APs are antegrade pathway conduction \u2264250 ms in baseline or during the adrenergic stimulus, inducibility of atrioventricular reciprocating tachycardias (AVRT), inducibility of pre\u2010excited atrial fibrillation (AF), and presence of multiple APs. For all of these transcatheter ablation is recommended. The aim of our study was to evaluate the existence of differences in risk characteristics between patients with intermittent pre\u2010excitation (IPX) and those with persistent pre\u2010excitation (PPX), from a sample of adults with ventricular pre\u2010excitation and symptoms like palpitations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>293 adults [IPX: 51 (17.4%); PPX: 242 (82.6%)] underwent electrophysiological study and then catheter ablation of their APs if arrhythmia inducibility (AVRT\/AF) was noted, or, conversely, if it was appreciated a fast AP antegrade conduction, in baseline or during intravenous isoproterenol infusion, or if multiple APs were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no statistically significant differences in demographic characteristics (age and gender), AVRT\/AF inducibility, antegrade conductive properties, the prevalence of multiple APs, and APs locations between IPX and PPX patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study, patients with IPX did not show significant differences in clinical and electrophysiological features versus PPX patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14798","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T16:45:04Z","timestamp":1690908304000},"page":"1049-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intermittent ventricular pre\u2010excitation in symptomatic adults: Always a marker of low risk?"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2150-3788","authenticated-orcid":false,"given":"Antonio Gianluca","family":"Robles","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"},{"name":"Cardiology Unit \u201cL. Bonomo\u201d Hospital Andria Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-6654","authenticated-orcid":false,"given":"Zefferino","family":"Palam\u00e0","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Public Health, Life and Environmental Science University of L'Aquila L'Aquila Italy"},{"name":"Villa Verde C.D.C. Health Centre Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Pernat","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit University Medical Center Ljubljana (UMCL) Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Gianfrancesco","sequence":"additional","affiliation":[{"name":"Cardiology Unit \u201cL. 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