{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:05Z","timestamp":1787015945566,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prediction of the chamber of origin in patients with outflow tract ventricular arrhythmias (OTVA) remains challenging. A clinical risk score based on age, sex and presence of hypertension was associated with a left ventricular outflow tract (LVOT) origin. We aimed to validate this clinical score to predict an LVOT origin in patients with OTVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a two\u2010center observational cohort study, unselected patients undergoing catheter ablation (CA) for OTVA were enrolled. All procedures were performed using an electroanatomical mapping system. Successful ablation was defined as a \u226580% reduction of the initial overall PVC burden after 3 months of follow\u2010up. Patients with unsuccessful ablation were excluded from this analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 187 consecutive patients with successful CA of idiopathic OTVA. Mean age was 52\u00a0\u00b1\u00a015 years, 102 patients (55%) were female, and 74 (40%) suffered from hypertension. A LVOT origin was found in 64 patients (34%). A score incorporating age, sex and presence of hypertension reached 73% sensitivity and 67% specificity for a low (0\u20131) and high (2\u20133) score, to predict an LVOT origin. The combination of one ECG algorithm (V\n                      <jats:sub>2<\/jats:sub>\n                      S\/V\n                      <jats:sub>3<\/jats:sub>\n                      R\u2010index) with the clinical score resulted in a sensitivity and specificity of 81% and 70% for PVCs with R\/S transition at V\n                      <jats:sub>3<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The published clinical score yielded a lower sensitivity and specificity in our cohort. However, for PVCs with R\/S transition at V\n                      <jats:sub>3,<\/jats:sub>\n                      the combination with an existing ECG algorithm can improve the predictability of LVOT origin.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.14809","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:56:04Z","timestamp":1692885364000},"page":"1186-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validation of a clinical model for predicting left versus right ventricular outflow tract origin of idiopathic ventricular arrhythmias"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-342X","authenticated-orcid":false,"given":"Luc","family":"Bourquin","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Research Institute Basel (CRIB) University Hospital 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