{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:04Z","timestamp":1747187464510,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite undergoing a single ablation, many patients with paroxysmal atrial fibrillation (PAF) experience a gradually increasing recurrence rate. This study aims to examine the relationship between left atrial appendage emptying velocity (LAAeV) and filling velocity (LAAfV) profiles and 3\u2010year recurrence of AF after ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective study of 658 consecutive PAF patients who underwent their first ablation between January 2018 and December 2019. We collected the clinical and echocardiographic characteristics of the patients. LAAeV and LAAfV were obtained from a transesophageal echocardiogram (TEE) before catheter ablation. Patients were followed at regular intervals to monitor for the primary outcome of AF recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After a median follow\u2010up period of 35.3 months (range, 10.7\u201336.3), 288 patients (43.8%) experienced AF recurrence after catheter ablation. Patients who experienced AF recurrence had decreased LAAeV and LAAfV (LAAeV: 56.5\u00a0\u00b1\u00a021.2\u00a0vs. 59.6\u00a0\u00b1\u00a020.7\u00a0cm\/s, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.052; LAAfV: 47.5\u00a0\u00b1\u00a017.9\u00a0vs. 51.7\u00a0\u00b1\u00a018.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). Kaplan\u2013Meier analysis showed that patients in the low LAAeV\u00a0(&lt;55\u00a0cm\/s) group had a poorer event\u2010free survival rate than those in the high LAAeV (\u226555\u00a0cm\/s) group (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012). Patients with LAAfV\u00a0&lt;48\u00a0cm\/s had a significantly higher risk of AF recurrence than those with LAAfV \u226548\u00a0cm\/s (log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). In the multivariable model, low LAAfV pre\u2010ablation in TEE\u2010guided was significantly independently associated with 3\u2010year recurrence after single radiofrequency ablation in patients with PAF, along with LA dimension and duration of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found an independent association between low LAAfV pre\u2010ablation in TEE\u2010guided and 3\u2010year recurrence after single radiofrequency ablation in patients with PAF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14828","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T08:16:53Z","timestamp":1695370613000},"page":"1412-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of pre\u2010ablation left appendage flow velocities on long term recurrence of catheter ablation for paroxysmal atrial fibrillation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6072-5861","authenticated-orcid":false,"given":"Jing","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Jun","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-1827","authenticated-orcid":false,"given":"Ri\u2010Bo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-4421","authenticated-orcid":false,"given":"Cai\u2010Hua","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De\u2010Yong","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-7805","authenticated-orcid":false,"given":"Jian\u2010Zeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5387-5957","authenticated-orcid":false,"given":"Chang\u2010Sheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing An Zhen 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