{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:14:10Z","timestamp":1771629250874,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recently, a new cryoballoon (CB) technology (POLARx; Boston Scientific) has come onto the market. Preliminary data have shown that its acute safety and efficacy are similar to those of the first\u2010generation CB. The aim of this study was to assess the medium\u2010term outcome of pulmonary vein isolation (PVI) with the POLARxTM CB in a large multicenter registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively collected data on 125 consecutive patients with paroxysmal atrial fibrillation (AF) who underwent PVI by means of a novel CB system. Two cases of transient phrenic nerve palsy occurred, with full recovery in the 48h post procedure; no major procedure\u2010related adverse events were reported. During the 90\u2010day blanking period, 4 (3.2%) patients experienced an early recurrence. After the blanking period, over a mean follow\u2010up of 411\u00a0\u00b1\u00a062 days, 19 patients (15.2%) suffered an AF\/atrial tachycardia (AT) recurrence. The 1\u2010year freedom from AF\/AT recurrence was 86.4% (<jats:italic>n<\/jats:italic>\u00a0=\u00a017): 10 (8%) patients had an AF recurrence, 6 (4.8%) had an AT occurrence and 1 (0.8%) suffered both events. Patients with AF\/AT recurrences had both a shorter deflation time and total deflation time. Moreover, CB ablations with measured TTI\u00a0&lt;\u00a090 s and TTI\u00a0&lt;\u00a060 s were more frequent in patients without AF\/AT recurrence (88.5% and 77.4%, respectively) than in those who experienced at least one AF\/AT recurrence (67.5% and 55.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel POLARx cryo\u2010balloon system is safe and effective for PV isolation, displaying a 1\u2010year freedom from atrial arrhythmia recurrence of 86.4%, which is in line to that reported with AFA\u2010Pro CB or RF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p>Catheter Ablation of Arrhythmias with a High\u2010Density Mapping System in Real\u2010World Practice (CHARISMA). URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/\">http:\/\/clinicaltrials.gov\/<\/jats:ext-link> Identifier: NCT03793998. Registration date: January 4, 2019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14839","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T10:51:02Z","timestamp":1697539862000},"page":"1302-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pulmonary vein isolation by means of a novel cryoballoon technology in paroxysmal atrial fibrillation patients: 1\u2010year outcome from a large Italian multicenter clinical registry"],"prefix":"10.1111","volume":"46","author":[{"given":"Stefano","family":"Bianchi","sequence":"first","affiliation":[{"name":"Arrhythmology Unit San Giovanni Calibita Hospital Fatebefratelli  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"De Simone","sequence":"additional","affiliation":[{"name":"Laboratorio di Elettrofisiologia Clinica San Michele  Maddaloni Caserta Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-1110","authenticated-orcid":false,"given":"Saverio","family":"Iacopino","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, Ravenna  Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Fassini","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology &amp; Cardiac Pacing Centro Cardiologico Monzino, IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-0334","authenticated-orcid":false,"given":"Maurizio","family":"Malacrida","sequence":"additional","affiliation":[{"name":"Boston Scientific  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Rossi","sequence":"additional","affiliation":[{"name":"Arrhythmology Unit San Giovanni Calibita Hospital Fatebefratelli  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4646-0865","authenticated-orcid":false,"given":"Giuseppe","family":"Stabile","sequence":"additional","affiliation":[{"name":"Laboratorio di Elettrofisiologia Clinica San Michele  Maddaloni Caserta Italy"},{"name":"Mediterranea Cardiocentro  Napoli Italy"},{"name":"Anthea Hospital  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Petretta","sequence":"additional","affiliation":[{"name":"Maria Cecilia Hospital, Ravenna  Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Tundo","sequence":"additional","affiliation":[{"name":"Department of Clinical Electrophysiology &amp; 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