{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:07Z","timestamp":1747187467873,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Reports on the factors predicting long\u2010term survival of CRT\u2010D cases from Western countries are increasing, however, those from Asia including Japan are still sparse. We aimed to clarify the factors predicting long\u2010term survival of Japanese CRT\u2010D cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed consecutive 133 patients who underwent CRT\u2010D implantation between 2006 and 2021. We compared clinical factors between patients who died within 5 years after implantation (short\u2010survival group: <jats:italic>n<\/jats:italic>\u00a0=\u00a031) and who had survived for more than 5 years (long\u2010survival group: <jats:italic>n<\/jats:italic>\u00a0=\u00a036) after implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Major underlying heart diseases were dilated cardiomyopathy (45%) and ischemic heart disease (12%). There was no difference between the short\u2010survival group and the long\u2010survival group in incidence of CLBBB (32%\u00a0vs. 30%), whereas CRBBB was more common in the short\u2010survival group (26%\u00a0vs. 0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). Mechanical dyssynchrony at implantation was more frequent in the long\u2010survival group (48%\u00a0vs. 78%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). The incidence of response to CRT at 1 year after implantation was higher in long\u2010survival group (19%\u00a0vs. 50%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). Multiple logistic regression analysis identified NYHA class, mechanical dyssynchrony at implantation, and response at one year as predictors of long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Japanese CRT\u2010D cases, lower NHYA class, preexisting mechanical dyssynchrony, and 1\u2010year response to CRT predict long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14848","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T17:59:01Z","timestamp":1697911141000},"page":"1484-1490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of long\u2010term survival in Japanese patients with heart failure with reduced ejection fraction (HFrEF) treated with cardiac resynchronization therapy\u2010defibrillators (CRT\u2010D)"],"prefix":"10.1111","volume":"46","author":[{"given":"Yuta","family":"Sakaguchi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhythm","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Akagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Niigata University Graduate School of Medical and 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