{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T18:49:08Z","timestamp":1773686948646,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1307800 [AH17]"],"award-info":[{"award-number":["2017YFC1307800 [AH17]"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The cardiac resynchronization therapy (CRT) non\u2010response rate can reach 30% in heart failure (HF) patients with left bundle branch block (LBBB). This study aimed to evaluate the value of baseline q waves in leads I, V5, or V6 in predicting response to CRT in patients with HF and LBBB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with HF (left ventricular ejection fraction \u226435%) and LBBB receiving CRT implantation were retrospectively enrolled. Baseline characteristics and electrocardiogram parameters, including lateral and left precordial q waves were evaluated. Non\u2010response to CRT was defined as the improvement of left ventricular ejection fraction (LVEF)\u00a0&lt;\u00a05% at a 6\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 132 patients (mean age 63.0\u00a0\u00b1\u00a010.4 years, 94 [71.2%] male) were included. Among them, 32 patients with q waves in leads I, V5, or V6 were classified into the qLBBB (+) group, and the rest without q waves in these leads were defined as the qLBBB (\u2010) group. The CRT non\u2010response rate in the qLBBB (+) group was markedly higher than that in the qLBBB (\u2010) group (68.8%\u00a0vs. 33.3%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Multivariable logistic regression analysis revealed that the presence of baseline q waves in leads I, V5, or V6 remained significantly associated with a higher rate of CRT non\u2010response in patients with HF and LBBB (odds ratio: 4.8, 95% confidence interval: 1.5\u201315.0, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Any q wave in leads I, V5, or V6 was an independent predictive factor for CRT non\u2010response in patients with HF and LBBB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14854","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T12:09:00Z","timestamp":1701346140000},"page":"177-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Value of q waves in lateral and left precordial leads in patients with left bundle branch block to predict the response to cardiac resynchronization\u00a0therapy"],"prefix":"10.1111","volume":"47","author":[{"given":"Shimeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Gu","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8755-6965","authenticated-orcid":false,"given":"Mingfang","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-486X","authenticated-orcid":false,"given":"Minglong","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_11_3_1","first-page":"e895","article-title":"2022 aha\/acc\/hfsa guideline for the management of heart failure: a report of the American college of cardiology\/American heart association joint committee on clinical practice guidelines","volume":"145","author":"Heidenreich PA","year":"2022","journal-title":"Circulation"},{"key":"e_1_2_11_4_1","first-page":"1463","article-title":"Avoiding non\u2010responders to cardiac resynchronization therapy: a practical guide","volume":"38","author":"Daubert C","year":"2017","journal-title":"Eur Heart J"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09834-w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz168"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw326"},{"key":"e_1_2_11_8_1","first-page":"1850","article-title":"The value of the 12\u2010lead electrocardiogram in localizing the scar in non\u2010ischaemic cardiomyopathy","volume":"18","author":"Oloriz T","year":"2016","journal-title":"Europace"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.894774"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2036545"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12750"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.09.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht150"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191095"},{"key":"e_1_2_11_16_1","first-page":"192","article-title":"Interpreting myocardial perfusion scintigraphy using single\u2010photon emission computed tomography. 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