{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:11Z","timestamp":1747187471012,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970269"],"award-info":[{"award-number":["81970269"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with non\u2010valvular atrial fibrillation (NVAF) and previous stroke have a significantly higher risk of stroke recurrence. This study aimed to examine the safety and efficacy of the LAmbre left atrial appendage occlusion device in NVAF patients with a history of stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 103 consecutive NVAF patients in 11 Chinese medical centers who had a history of stroke or transient ischemic attacks (TIA) and underwent placement of the LAmbre device. Follow\u2010up was conducted 1, 3, 6, and 12 months after the procedure. The primary endpoints were the incidence of new ischemic or hemorrhagic stroke, TIA, systemic embolism, or cardiac death. Secondary endpoints were serious perioperative or device\u2010related complications and cerebral, gastrointestinal, or other bleeding events requiring transfusion of at least 2 units of packed red blood cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean patient age was 67.63\u00a0\u00b1\u00a07.14 years; mean CHA2DS2\u2010VASc score was 4.72\u00a0\u00b1\u00a01.18 and mean HAS\u2010BLED score was 1.90\u00a0\u00b1\u00a01.00. LAmbre device placement was successful in 101 patients (98.05%). Mean follow\u2010up was 12.2 months. Five patients (4.95%) developed a new pericardial effusion after the procedure; none required treatment. Eighty\u2010six patients (85.15%) exhibited no peri\u2010device leak (PDL). However, 13 (12.8%) had a small (0\u20133\u00a0mm) PDL and two (2.3%) had a moderate PDL (3\u20135\u00a0mm). One recurrent stroke occurred during follow\u2010up (1.1%). No other complications occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This multicenter study shows the safety and efficacy of LAmbre left atrial appendage occlusion for NVAF patients with a history of stroke or TIA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14866","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T13:28:18Z","timestamp":1699536498000},"page":"1478-1483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left atrial appendage occlusion using the LAmbre device in atrial fibrillation patients with a history of ischemic stroke: 1\u2010Year outcomes from a multicenter study in China"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4866-2372","authenticated-orcid":false,"given":"Abdul Basit","family":"Bangash","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuechun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-134X","authenticated-orcid":false,"given":"Weijian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingquan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Qilu Hospital of Shandong University Jinan Shandong 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