{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T18:07:18Z","timestamp":1772906838298,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The real\u2010world data on the safety profile of transvenous lead extraction (TLE) for infected cardiac implantable electronic devices (CIED) among elderly patients is not well\u2010established. This study aimed to evaluate the hospital outcomes between patients of different age groups who underwent TLE for infected CIED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using the Nationwide Readmissions Database, our study included patients aged \u226518 years who underwent TLE for infected CIED between 2017 and 2020. We divided the patients into four groups: Group A. Young (&lt;50 years), Group B. Young intermediate (50\u201369 years old), Group C. Older intermediate (70\u201379 years old), and Group D. Octogenarian (\u226580 years old). We then analyzed the in\u2010hospital outcome and 30\u2010day readmission between these age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10,928 patients who were admitted for TLE of infected CIED were included in this study: 982 (9.0%) patients in group A, 4,234 (38.7%) patients in group B, 3,204 (29.3%) patients in group C and 2,508 (23.0%) of patients in group D. Our study demonstrated that the risk of early mortality increased with older age (Group B vs. Group A: OR: 1.92, 95% CI: 1.19\u20103.09, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01; Group C vs. Group A: OR: 2.47, 95% CI: 1.51\u20104.04, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01; Group D vs. Group A: OR: 2.82, 95% CI: 1.69\u20104.72, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). The risk of non\u2010home discharge also increased in elderly groups (Group B vs. Group A: OR: 1.89; 95% CI: 1.52\u20102.36; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01; Group C vs. Group A: OR: 2.82; 95% CI 2.24\u20103.56; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01; Group D vs. Group A: OR: 4.16; 95% CI: 3.28\u20105.28; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). There was no significant difference in hospitalization length and 30\u2010day readmission between different age groups. Apart from a higher rate of open heart surgery in group A, the procedural complications were comparable between these age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elderly patients had worse in\u2010hospital outcomes in early mortality and non\u2010home discharge following the TLE for infected CIED. There was no significant difference between elderly and non\u2010elderly groups in prolonged hospital stay and 30\u2010day readmission. Elderly patients did not have a higher risk of procedural complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14939","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:32:36Z","timestamp":1707294756000},"page":"577-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of age on in\u2010hospital outcomes of transvenous lead extraction for infected cardiac implantable electronic device"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-8934","authenticated-orcid":false,"given":"Min Choon","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"},{"name":"Department of Internal Medicine New York Medical College at Saint Michael's Medical Center  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi Xuan","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sparrow Health System and Michigan State University  East Lansing Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-7236","authenticated-orcid":false,"given":"Yong Hao","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Pediatrics Beaumont Health  Royal Oak Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Yean","family":"Thong","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Medical College  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneesh","family":"Tolat","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Hartford Healthcare\/University of Connecticut  Hartford Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis R.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin Z.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.01.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.033"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.09.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.07.024"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut410"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.08.006"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.964270"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2012.03400.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14310"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx080"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.12.023"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.11.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.02.042"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.3379"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.976076"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.070"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13769-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.06.009"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13715"}],"container-title":["Pacing 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