{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:39:49Z","timestamp":1752982789254,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrioventricular block (AVB) secondary to transient causes can recover with its correction. However, studies assessing predictors of recovery and long\u2010term recurrence are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with advanced or complete AVB who had a reversible cause admitted in a single expert center were retrospectively studied. Patients with AVB secondary to acute coronary syndromes were excluded from analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a population of 162 patients, the main factors associated with recovery of rhythm without a permanent pacemaker (PPM) implantation were the presence of chronic kidney disease (CKD) on dialysis (OR 7.6; CI 95% 1.2\u201347.5 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03)); greater serum potassium levels (OR 2.3; CI 95% 1.28\u20134.0 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01)), higher dosage of bradycardic drugs (OR 2.2; CI 95% 1.13\u20134.4 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02)), the association between different bradycardic drugs (OR 9.0; CI 95% 2.02\u201340.3 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01)) and between drug therapy and hyperkaliemia (OR 5.2; CI 95% 1.8\u201315.1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01)). There was an overall high burden of conductions abnormalities which did not correlate with recovery of rhythm (OR 0.5; CI 95% 0.19\u20131.5 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.23)). In 29 patients (17.9%) there was a correction of the AVB. During a maximum follow\u2010up of 130 months, 24 patients (82.8%) had a recurrence which warranted a PPM. In the overall cohort only five patients (3%) had sustained recovery of rhythm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recovery of AVB was mainly observed with higher doses of drug therapy, higher serum potassium levels or a combination of factors and regardless of baseline conduction abnormalities. The high rate of recurrence during follow\u2010up warrants a close follow\u2010up or PPM implantation at index admission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14957","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T14:04:12Z","timestamp":1708956252000},"page":"483-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atrioventricular block secondary to transient causes and long\u2010term recurrence after an index event"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0481-5894","authenticated-orcid":false,"given":"Jo\u00e3o Grade","family":"Santos","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Martinho","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diogo","family":"Cunha","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Briosa","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Miranda","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Almeida","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lder","family":"Pereira","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Garcia de Orta Almada Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_9_3_1","first-page":"e506","article-title":"2018 ACC\/AHA\/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. 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