{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:43:23Z","timestamp":1785408203475,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The study explores left atrial appendage closure (LAAC) as a safe and effective alternative to anticoagulation for atrial fibrillation (AF) patients at high bleeding risk. Complications, such as cardioembolic events due to left atrial appendage thrombus (LAAT), highlight the need for alternative stroke prevention strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This research assesses LAAC's safety and efficacy in patients with LAAT, aiming to offer valuable insights into its potential as a viable option for stroke prevention in such cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 205 patients who underwent LAAC using specific devices between September 2015 and February 2023. Among them, 32 patients had persistent LAAT. Baseline characteristics, antithrombotic medications, risk scores, and LAAC indications were documented. Patients were followed to monitor significant clinical events like stroke, cardiovascular mortality, and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 71.9 and mostly female. Indications for LAAC were ischemic cerebrovascular events (CVE) despite anticoagulation (25%), bleeding complications (major\/minor, 37.5% each), or both. Successful LAA closure was achieved in all cases, with minimal pericardial effusion in one. One\u2010month follow\u2010up showed no major events or device\u2010related issues. Median follow\u2010up of 16.5 months saw 21.9% non\u2010cardiac deaths. The study underscores LAAC's efficacy for stroke prevention in patients with persistent LAAT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LAAC in cases of LAAT, whether pursued initially or as a deferred approach, demonstrates feasibility and safety, exhibiting notable procedural success and minimal incidence of periprocedural complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14969","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T07:40:11Z","timestamp":1710315611000},"page":"583-590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Should left atrial appendage closure be considered in resistant left atrial appendage thrombus cases? \u2018Former Foe, New Ally\u2019"],"prefix":"10.1111","volume":"47","author":[{"given":"Ahmet Hakan","family":"Ates","sequence":"first","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-8436","authenticated-orcid":false,"given":"Ahmet","family":"Kivrak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugur Nadir","family":"Karakulak","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Coteli","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7673-229X","authenticated-orcid":false,"given":"Hikmet","family":"Yorgun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Levent","family":"Sahiner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ergun","family":"Bar\u0131s Kaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kudret","family":"Aytemir","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hacettepe University Faculty of Medicine Ankara 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Amulet\u2122 device: real life data with mid\u2010term follow\u2010up results","volume":"113","author":"\u015eahiner ML","year":"2019","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2021-319811"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00777"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29161"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14398"}],"container-title":["Pacing and Clinical 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