{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:27Z","timestamp":1747187487832,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Left bundle branch block (LBBB) induced cardiomyopathy is an increasingly recognized disease entity.\u00a0 However, no clinical testing has been shown to be able to predict such an occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 70\u2010year\u2010old male with a prior history of LBBB with preserved ejection fraction (EF) and no other known cardiovascular conditions presented with presyncope, high\u2010grade AV block, and heart failure with reduced EF (36%). His coronary angiogram was negative for any obstructive disease. No other known etiologies for cardiomyopathy were identified. Artificial intelligence\u2010enabled ECGs performed 6 years prior to clinical presentation consistently predicted a high probability (up to 91%) of low EF. The patient successfully underwent left bundle branch area (LBBA) pacing with correction of the underlying LBBB. Subsequent AI ECGs showed a large drop in the probability of low EF immediately after LBBA pacing to 47% and then to 3% 2 months post procedure. His heart failure symptoms markedly improved and EF normalized to 54% at the same time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Artificial intelligence\u2010enabled ECGS may help identify patients who are at risk of developing LBBB\u2010induced cardiomyopathy and predict the response to LBBA pacing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.14980","type":"journal-article","created":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T09:08:25Z","timestamp":1712480905000},"page":"776-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful prediction of left bundle branch block\u2010induced cardiomyopathy and treatment effect by artificial intelligence\u2010enabled electrocardiogram"],"prefix":"10.1111","volume":"47","author":[{"given":"Rahul","family":"Dhawan","sequence":"first","affiliation":[{"name":"Mayo Clinic Rochester  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Omer","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System  La Crosse Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Mayo Clinic Health System  La Crosse Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-2948","authenticated-orcid":false,"given":"Paul A.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoke","family":"Liu","sequence":"additional","affiliation":[{"name":"Mayo Clinic Rochester  Rochester Minnesota USA"},{"name":"Mayo Clinic Health System  La Crosse Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1016\/j.jacc.2018.09.069"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1054\/jcaf.2003.193"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.jchf.2016.07.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/j.amjcard.2017.08.003"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1016\/j.hrthm.2016.09.027"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1016\/j.hrthm.2016.09.027"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1093\/europace\/euae007"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1016\/j.jacep.2021.02.004"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1016\/j.jacep.2020.08.015"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.3389\/fcvm.2021.669301"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1016\/j.jacc.2022.07.019"},{"key":"e_1_2_8_13_1","first-page":"151","article-title":"Predictors of pacemaker\u2010induced cardiomyopathy and importance of nutritional status and prognostic nutritional index","volume":"38","author":"Balli M","year":"2022","journal-title":"Acta Cardiol Sin"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.14980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:57:51Z","timestamp":1718704671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.14980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,7]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/pace.14980"],"URL":"https:\/\/doi.org\/10.1111\/pace.14980","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"type":"print","value":"0147-8389"},{"type":"electronic","value":"1540-8159"}],"subject":[],"published":{"date-parts":[[2024,4,7]]},"assertion":[{"value":"2024-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}