{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:51:51Z","timestamp":1788184311341,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Closed Loop Stimulation (CLS) is a rate\u2010responsive algorithm that adjusts heart rate (HR) based on changes in intracardiac impedance measured from the right ventricle lead. However, the use of CLS in conduction system pacing has not been investigated. In this retrospective study, we aimed to assess whether CLS with left bundle branch area pacing (LBBAP) can generate an appropriate distribution of HR in daily life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Our study included 24 patients with CLS pacing and chronotropic incompetence, comparing them with 19 patients receiving DDD pacing, all with LBBAP. Cumulative HR distribution charts were generated using data from a single device interrogation with a minimum follow\u2010up period of 30 days. In DDD\u2010CLS mode, there was a higher percentage of atrial pacing compared to DDD mode (median 58% [interquartile range 29%\u201083%] vs. 13% [10%\u201026%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), and CLS\u2010paced beats were present across all frequency bins. The distribution of beats between the groups was similar (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.643), resulting in comparable mean HR (72 bpm [70\u201077] vs. 73 bpm [65\u201075], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.615).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the context of LBBAP, CLS effectively modulates pacing rates over a wide frequency range. This lead position does not adversely affect the rate\u2010responsive performance of the algorithm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15022","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T14:44:35Z","timestamp":1717857875000},"page":"1276-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Closed loop stimulation in left bundle branch area pacing"],"prefix":"10.1111","volume":"47","author":[{"given":"Gabriele","family":"Dell'Era","sequence":"first","affiliation":[{"name":"Clinica Cardiologica Dipartimento Toraco\u2010Cardio\u2010Vascolare Ospedale Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-3207","authenticated-orcid":false,"given":"Chiara","family":"Ghiglieno","sequence":"additional","affiliation":[{"name":"Clinica Cardiologica Dipartimento Toraco\u2010Cardio\u2010Vascolare Ospedale Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"De Vecchi","sequence":"additional","affiliation":[{"name":"Clinica Cardiologica Dipartimento Toraco\u2010Cardio\u2010Vascolare Ospedale Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Santagostino","sequence":"additional","affiliation":[{"name":"Clinica Cardiologica Dipartimento Toraco\u2010Cardio\u2010Vascolare Ospedale Maggiore della Carit\u00e0  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Annunziata","sequence":"additional","affiliation":[{"name":"Clinical Unit Biotronik Italia  Vimodrone Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"Clinical Unit Biotronik Italia  Vimodrone Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-7944","authenticated-orcid":false,"given":"Daniele","family":"Giacopelli","sequence":"additional","affiliation":[{"name":"Clinical Unit Biotronik Italia  Vimodrone Lombardia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Patti","sequence":"additional","affiliation":[{"name":"Clinica Cardiologica Dipartimento Toraco\u2010Cardio\u2010Vascolare Ospedale Maggiore della Carit\u00e0  Novara Italy"},{"name":"Universit\u00e0 del Piemonte Orientale Amedeo Avogadro  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2003.00022.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00795.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2021.45"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.09.013"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad043"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.03.1538"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac445"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.03.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14777"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2022.03.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.04.032"}],"container-title":["Pacing 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Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.15022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T09:31:07Z","timestamp":1732008667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.15022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,8]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/pace.15022"],"URL":"https:\/\/doi.org\/10.1111\/pace.15022","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,8]]},"assertion":[{"value":"2023-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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