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This study aimed to investigate sex disparities in CS patients undergoing ICD implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The 2016\u20132020 National Inpatient Sample (NIS) database compared the characteristics and outcomes of males and females with CS receiving ICDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 760 CS patients who underwent inpatient ICD implantation, 66.4% were male. Males were younger (55.0\u00a0vs. 56.9 years, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), had higher rates of diabetes (31.7%\u00a0vs. 21.6%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) and chronic kidney disease (CKD) (16.8%\u00a0vs. 7.8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) but lower prevalence of atrial fibrillation (AF) (11.9%\u00a0vs. 23.5%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01), sick sinus syndrome (4.0%\u00a0vs. 7.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024), ventricular fibrillation (VF) (9.9%\u00a0vs. 15.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02), and black ancestry (31.9%\u00a0vs. 58.0%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). Unadjusted major adverse cardiovascular events (MACE), defined as a composite of in\u2010hospital death, myocardial infarction (MI), and ischemic stroke, was higher in females (11.8%\u00a0vs. 6.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.024), but when adjusted for age and tCharlson Comorbidity Index (CCI), females demonstrated significantly lower odds of experiencing MACE (aOR: 0.048, 95% CI: 0.006\u20130.395, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). Incidence of acute kidney injury (AKI) post\u2010ICD was significantly lower in females (15.7%\u00a0vs. 23.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) as was the adjusted odds (aOR: 0.282, 95% CI: 0.146\u20130.546, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). There was comparable mean length of stay and hospital charges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ICD utilization in CS patients is more common among males, who have a higher prevalence of diabetes and CKD but a lower prevalence of AF, sick sinus syndrome, and VF. Adjusted MACE and AKI were significantly lower in females.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15051","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T18:58:31Z","timestamp":1722365911000},"page":"1394-1403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sex disparities in cardiac sarcoidosis patients undergoing implantable cardioverter\u2010defibrillator implantation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-7314","authenticated-orcid":false,"given":"Raheel","family":"Ahmed","sequence":"first","affiliation":[{"name":"Royal Brompton Hospital, part of Guy's and St Thomas\u2019 NHS Foundation Trust  London UK"},{"name":"National Heart and Lung Institute, Imperial College London  London 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