{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:35Z","timestamp":1787015915387,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T00:00:00Z","timestamp":1727481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070521"],"award-info":[{"award-number":["82070521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For the initial treatment strategy for patients with cardiac resynchronization therapy (CRT) indications, whether to choose left bundle branch area pacing (LBBaP) or biventricular pacing (BVP) remains controversial. We aimed to investigate the cost\u2010effectiveness ratio (CER) of LBBaP and BVP in heart failure (HF) patients with left bundle branch block (LBBB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational study included HF patients with LBBB who underwent successful LBBaP or BVP. The primary outcomes were echocardiographic response (left ventricular ejection fraction [LVEF] increase \u22655%), LVEF improvement, hospitalization costs, and CER (CER = cost\/echocardiographic response rate). Secondary outcomes included other echocardiographic parameters, New York Heart Association (NYHA), N\u2010terminal pro\u2013B\u2010type natriuretic peptide (NT\u2010proBNP), pacemaker parameters, complications, ventricular arrhythmia (VA) events, HF hospitalization (HFH), and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 130 patients (85 LBBaP and 45 BVP) were included (65.6 \u00b1 10.0 years, 70.77% men). The median follow\u2010up period was 16(12,30), months. Compared with BVP, the LBBaP group showed a greater increase in LVEF (20.2%\u00a0\u00b1\u00a011.8% vs. 10.5%\u00a0\u00b1\u00a013.9%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), higher echocardiographic response rate (86.1% vs. 57.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and lower hospitalization costs [$9707.7 (7751.2, 18,088.5) vs. $20,046.1 (18,840.1, 22,447.3);\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001]. The CER was 112.7 and 346.8 in LBBaP and BVP, respectively. The incremental cost\u2010effectiveness ratio (ICER = \u25b3cost\/\u25b3echocardiographic response rate) was $\u2212365.3\/per 1% increase in effectiveness. LBBaP improved cardiac function more significantly than BVP. There were no significant differences in clinical outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LBBaP\u2010CRT is more cost\u2010effective than BVP, offering greater LVEF improvement, higher echocardiographic response rates, lower hospitalization costs, and more significantly improved cardiac function. These findings need large randomized clinical trials for further confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.15077","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T08:44:18Z","timestamp":1727513058000},"page":"1539-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cost\u2010Effectiveness Ratio Analysis of LBBaP Versus BVP in Heart Failure Patients With LBBB"],"prefix":"10.1111","volume":"47","author":[{"given":"Shengchan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0139-2352","authenticated-orcid":false,"given":"Zhixin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwei","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Montefiore Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology First Affiliated Hospital Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational Medicine Nanjing Medical University  Nanjing 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Pacing vs. Optimized Biventricular Pacing With Adaptive Algorithm in Heart Failure With Left Bundle Branch Block: A Prospective, Multi\u2010centre, Observational Study","volume":"24","author":"Chen X.","year":"2022","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14628"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2018.07.010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001380"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12731"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.05.019"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.04.037"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.02.018"}],"container-title":["Pacing and Clinical 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