{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:27:30Z","timestamp":1783546050975,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970288"],"award-info":[{"award-number":["81970288"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2019B020230004"],"award-info":[{"award-number":["2019B020230004"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2020B1111170011"],"award-info":[{"award-number":["2020B1111170011"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Treating recurrent atrial arrhythmias after persistent atrial fibrillation (PeAF) ablation is often challenging. This single\u2010center, prospective study aimed to observe the effectiveness of different combinations of oral antiarrhythmic drugs (AADs) in reverting to sinus rhythm (SR) in patients with recurrent atrial arrhythmias after PeAF ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five patients who experienced recurrent atrial arrhythmias after PeAF ablation were included. Based on their medication regimens, patients were divided into two groups, with the study group being a triple\u2010drug group (digoxin combined with amiodarone\/ propafenone and \u03b2\u2010blocker), and the control group being a non\u2010triple\u2010drug group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of reversion to SR was significantly higher in the study group (<jats:italic>n<\/jats:italic> = 29) than in the control group (<jats:italic>n<\/jats:italic> = 16) at 3 weeks (34.48% vs. 0%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and 1 month (44.84% vs. 6.25%, <jats:italic>p<\/jats:italic> = 0.02) after initiating AADs. No patients with asymptomatic bradycardia were observed in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>For patients with recurrent atrial arrhythmias after PeAF ablation, a regimen of low\u2010dose digoxin combined with amiodarone\/propafenone and \u03b2\u2010blocker may effectively improve short\u2010term reversion rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15083","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T10:14:41Z","timestamp":1728468881000},"page":"1642-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effectiveness of a Triple Antiarrhythmic Drug Strategy for Arrhythmia Recurrence after Persistent Atrial Fibrillation Ablation"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-6304","authenticated-orcid":false,"given":"Shuyu","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"},{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"},{"name":"The Second School of Clinical Medicine Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"},{"name":"School of Medicine South China University of Technology  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9110-9359","authenticated-orcid":false,"given":"Shulin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-0014","authenticated-orcid":false,"given":"Yumei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747493019897870"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.118"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv501"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.065"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01806-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)03375-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19116606"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.2.355"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030971"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.824847"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021375"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021328"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03230-X"},{"issue":"12","key":"e_1_2_11_17_1","first-page":"1764","article-title":"Safety and Efficacy of dronedarone From Clinical Trials to Real\u2010world Evidence: Implications for Its Use in Atrial Fibrillation","volume":"21","author":"Boriani G.","year":"2019","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology"},{"issue":"2","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/europace\/euab332","article-title":"The 2020 ESC Atrial Fibrillation Guidelines for Atrial Fibrillation Catheter Ablation, CABANA, and EAST","volume":"24","author":"Arbelo E.","year":"2022","journal-title":"Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057095"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-022-01743-z"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262030-00001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-4-503"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1998.tb00103.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456241"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200023060-00003"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.67.4.2170681"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu354"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.060"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2016.0016"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvab076"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80466-6"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198901000-00003"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.15083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T19:43:26Z","timestamp":1733859806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.15083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/pace.15083"],"URL":"https:\/\/doi.org\/10.1111\/pace.15083","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"2024-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}