{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:46:55Z","timestamp":1775886415087,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atrial high\u2010rate episodes (AHRE) have been linked to increased thromboembolic risk and all\u2010cause mortality in patients with cardiac implantable electronic devices (CIEDs). Various predictors of AHRE development have been identified, emphasizing the need for close monitoring and the potential transition to clinical atrial fibrillation (AF). However, the predictive value of P wave characteristics on AHRE development remains conflicting. This meta\u2010analysis aims to summarize existing data to investigate this association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We examined studies from MEDLINE and EMBASE databases up to May 2024 to investigate the association of baseline P\u2010wave duration (PWD), P\u2010wave dispersion (PWDIS), and interatrial block (IAB) with the risk of developing AHRE. We extracted the mean and standard deviations of PWD and PWDIS to calculate the pooled mean difference (MD). Risk ratios (RR) and 95% confidence intervals (CIs) were used to assess the association between IAB and AHRE risk, using the generic inverse variance method for combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The meta\u2010analysis included nine studies. Patients with AHRE had longer PWD and PWDIS compared to those without AHRE, with a pooled MD for PWD of 9.17\u00a0ms (95% CI: 4.74\u201313.60;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 47%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and a pooled MD for PWDIS of 20.56\u00a0ms (95% CI: 11.57\u201329.56;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 57%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Additionally, patients with IAB had a higher risk of developing AHRE, with a pooled RR of 3.33 (95% CI: 2.53\u20134.38;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), compared to those without IAB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our meta\u2010analysis found that patients with AHRE had higher PWD and PWDIS than those without AHRE. Additionally, IAB was associated with a higher risk of developing AHRE. These findings emphasize the importance of close monitoring and risk stratification, particularly for patients with P wave abnormalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.15084","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T11:48:32Z","timestamp":1728128912000},"page":"1548-1555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association Between P\u2010Wave Duration, Dispersion, and Interatrial Block and Atrial High\u2010Rate Episodes in CIED Patients"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-5269","authenticated-orcid":false,"given":"Phuuwadith","family":"Wattanachayakul","sequence":"first","affiliation":[{"name":"Department of Medicine Jefferson Einstein Hospital  Philadelphia Pennsylvania USA"},{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adivitch","family":"Sripusanapan","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Chiang Mai University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narathorn","family":"Kulthamrongsri","sequence":"additional","affiliation":[{"name":"Department of Medicine, John A. Burns School of Medicine University of Hawaii  Honolulu Hawai\u02bbi USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitchapong","family":"Prasitsumrit","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Napat","family":"Suriyathumrongkul","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Srinakharinwirot University  Nonthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abiodun","family":"Idowu","sequence":"additional","affiliation":[{"name":"Department of Medicine Jefferson Einstein Hospital  Philadelphia Pennsylvania USA"},{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0959-5576","authenticated-orcid":false,"given":"Jakrin","family":"Kewcharoen","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeet","family":"Mainigi","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"},{"name":"Division of Cardiovascular Disease Jefferson Einstein Hospital  Philadelphia Pennsylvania 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