{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:07:53Z","timestamp":1768680473094,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>His\u2010bundle pacing (HBP) is a pacing mode that provides near\u2010physiological pacing and has more advantages over standard right ventricle (RV) septum pacing in positive clinical results. However, traditional HBP cannot accurately and stably place the lead tip into the His\u2010Purkinje system. Hence, this study aimed to establish a novel strategy for HBP to strike a balance\u00a0between an excellent pacing threshold and minor injuries to the conduction system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HBP, using continuous and real\u2010time monitoring of unipolar His\u2010bundle (HB) electrograms along with electrocardiograms, was performed in 29 consecutive atrial fibrillation patients. We analyzed the unipolar HB intracardiac electrogram (EGM) and electrophysiological characteristics during HBP using John Jiang's connecting cable and an electrophysiology recording system. All patients were followed up for 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 29 patients, 28 (96.55%) successfully received HBP. Twenty\u2010one (75%) patients were confirmed to have the negative deflection of His potential with a negative amplitude of \u2265 0.1\u00a0mV in HB EGM. The subgroup with a deep negative deflection was recorded with an HBP threshold (0.71 \u00b1 0.41\u00a0V), significantly lower than those thresholds with no deep negative deflection (1.83 \u00b1 0.76\u00a0V) (<jats:italic>p<\/jats:italic> &lt; 0.05). The selective HBP rate was significantly different between the two groups: 20 (95.24%) in the deep negative deflection group and three (42.86%) in the\u00a0non\u2010deep negative deflection group (<jats:italic>p<\/jats:italic> &lt; 0.05); five (17.24%) patients presented right bundle branch block (RBBB) during the lead placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study supports the safety and feasibility of using an uninterrupted real\u2010time monitoring technique for HBP. An uninterrupted real\u2010time monitoring technique can guide the\u00a0accurate placement of the HB lead and may provide a\u00a0balance\u00a0between an\u00a0excellent pacing threshold and minor injury to the conduction system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15106","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T18:47:51Z","timestamp":1731782871000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electrophysiological Characteristics and Mechanism of His\u2010Bundle Pacing Guided by Electrocardiograms in Uninterrupted Real\u2010Time Monitoring Technique"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2678-7932","authenticated-orcid":false,"given":"Jinyan","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Cardiology Ningbo No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1934-5618","authenticated-orcid":false,"given":"Longfu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ningbo No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5806-6435","authenticated-orcid":false,"given":"Yuelin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ningbo No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ningbo No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengdong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ningbo No. 2 Hospital  Ningbo Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.8.869"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.01.056"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euq038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2016.07.006"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.09.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.03.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-020-00690-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00292.2020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.10.021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euy058"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.07.013"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2006.00543.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007415"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12571"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.15106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:58:18Z","timestamp":1741748298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.15106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,16]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/pace.15106"],"URL":"https:\/\/doi.org\/10.1111\/pace.15106","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,16]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}