{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:54Z","timestamp":1787015874448,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asymptomatic nonvalvular atrial fibrillation is often suspected in patients with cryptogenic stroke which constitute 20%\u201330% of ischemic strokes. Detection of atrial fibrillation (AF) and treatment with anticoagulation can reduce the risk of stroke. We sought to investigate the prevalence of asymptomatic atrial fibrillation (aAF) in patients with a history of stroke or an acute stroke on admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From November 2011 until December 2014, 15,308 patients with a first episode of AF were enrolled in phase 2 of the international, prospective, multicenter global registry on long\u2010term oral anticoagulation treatment in patients with AF (GLORIA\u2010AF) Registry. For the present analysis, we focused on patients with aAF regarding the prevalence of stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One third of patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 4892, 32%) had aAF. Of these, 611 (12.5%) had a history of stroke or an acute stroke on admission. In contrast, 519 of 10,416 (5.0%) patients with symptomatic AF (sAF) had a history of stroke or an acute stroke on admission. Higher age, male gender, permanent AF, stroke, and the combination of stroke, TIA or systemic embolism were associated with a higher prevalence of aAF on admission. In a multivariable analysis, patients with aAF had a 2.3\u2010fold (95% confidence interval (CI), 2.02\u20132.54) risk for stroke compared to patients with sAF. Other independent risk factors for stroke were a history of prior bleeding (odds ratio 1.62, 95% CI, 1.34\u20131.92), chronic kidney disease (1.38, 1.21\u20131.56), and diabetes mellitus (1.24, 1.10\u20131.41).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>aAF is reported in about one third of patients with newly diagnosed AF and is associated with a 2.3\u2010fold risk for stroke compared to sAF. Therefore, screening for aAF in high\u2010risk patients might be appropriate to prevent further embolic cerebrovascular events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.15113","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T21:33:28Z","timestamp":1732743208000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of Patients With Asymptomatic Atrial Fibrillation and Ischemic Stroke\u2014Insights From the GLORIA\u2010AF Registry (Phase 2)"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-9918","authenticated-orcid":false,"given":"Tobias","family":"Heer","sequence":"first","affiliation":[{"name":"Department of Cardiology M\u00fcnchen Klinik Neuperlach, Academic Teaching Hospital of LMU University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Zeymer","sequence":"additional","affiliation":[{"name":"Department of Cardiology Klinikum der Stadt Ludwigshafen am Rhein Ludwigshafen Germany"},{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Schwarzbach","sequence":"additional","affiliation":[{"name":"Department of Neurology Klinikum der Stadt Ludwigshafen am Rhein Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlheinz","family":"Seidl","sequence":"additional","affiliation":[{"name":"Westpfalz\u2010Klinikum Kaiserslautern Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Rauch\u2010Kr\u00f6hnert","sequence":"additional","affiliation":[{"name":"Department of Cardiology Charit\u00e9 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Marler","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharmaceuticals Ridgefield Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Teutsch","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim GmbH &amp; Co KG Ingelheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Christoph","family":"Diener","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Biometry and Epidemiology (IMIBE) University Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Senges","sequence":"additional","affiliation":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung Ludwigshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. 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